Journal:Acta Cryst F:S2053230X21013595
From Proteopedia
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<b>Molecular Tour</b><br> | <b>Molecular Tour</b><br> | ||
| - | Giardiasis or traveler's diarrhea can be fatal to the young, elderly, or immunocompromised. The Seattle Structural Genomics Center for Infectious Disease (SSGCID) has determined the structures of potential drug targets from ''Giardia lamblia''. Some of these proteins are hypothetical proteins that share < 30% sequence identity or less to proteins with known structure | + | Giardiasis or traveler's diarrhea can be fatal to the young, elderly, or immunocompromised. The Seattle Structural Genomics Center for Infectious Disease (SSGCID) has determined the structures of potential drug targets from ''Giardia lamblia''. Some of these proteins are hypothetical proteins that share < 30% sequence identity or less to proteins with known structure. |
[[Image:Figure3newa.png|left|450px|thumb|Despite the low sequence similarity the hypothetical protein is a prototypical YjgF/YER057c/UK114 endoribonucleases]] | [[Image:Figure3newa.png|left|450px|thumb|Despite the low sequence similarity the hypothetical protein is a prototypical YjgF/YER057c/UK114 endoribonucleases]] | ||
{{Clear}} | {{Clear}} | ||
| - | The atomic resolution structure of a 15.6 kDa protein was determined by molecular replacement. The structure has the 2-layer alpha-beta-sandwich topology observed in the prototypical endoribonucleases L-PSP with conserved allosteric active sites containing small molecules from the crystallization solution. This paper is an educational collaboration between Hampton University (an HBCU) and the Seattle Structural Genomics Center for Infectious Disease (SSGCID). | + | The atomic resolution structure of a 15.6 kDa protein was determined by molecular replacement. The structure has the 2-layer alpha-beta-sandwich topology observed in the prototypical endoribonucleases L-PSP with conserved allosteric active sites containing small molecules from the crystallization solution. These studies are part of ongoing studies to identify proteins that could be targeted for rational drug discovery for giardiasis. This paper is an educational collaboration between Hampton University (an HBCU) and the Seattle Structural Genomics Center for Infectious Disease (SSGCID). |
<b>References</b><br> | <b>References</b><br> | ||
Revision as of 14:02, 9 January 2022
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This page complements a publication in scientific journals and is one of the Proteopedia's Interactive 3D Complement pages. For aditional details please see I3DC.
