SARS-CoV-2 virus proteins
From Proteopedia
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| - | + | <StructureSection load='3rec' size='350' side='right' caption='Escherichia coli reca protein-bound DNA (PDB entry [[3rec]])' scene=''> | |
| - | <StructureSection load=' | + | {{Template:COVID Validation}} |
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| - | + | Anything in this section will appear adjacent to the 3D structure and will be scrollable. | |
| - | == Disease == | ||
| - | + | The genome of the SARS-CoV-2 virus codes for 28 proteins: | |
| - | + | Out of those, 19 have already been characterized structurally. | |
| - | + | <br> | |
| - | + | Details of the '''3D structure & function''' of the key proteins & RNA inside the virus can be seen in the NY Times [http://www.nytimes.com/interactive/2020/04/03/science/coronavirus-genome-bad-news-wrapped-in-protein.html '''''Bad News Wrapped in Protein: Inside the Coronavirus Genome''''']. | |
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| + | * [[SARS-CoV-2 Coronavirus Main Protease| Main protease]]: it is a cysteine protease that is essential for the viral life cycle. | ||
| + | * [[SARS-CoV-2_protein_NSP1|NSP1]]: ''Host translation inhibitor nsp1''. Inhibits host translation by interacting with the 40S ribosomal subunit. | ||
| + | * [[SARS-CoV-2_protein_NSP2|NSP2]]: ''Non-structural protein 2''. | ||
| + | * [[SARS-CoV-2 enzyme Papain-like|Papain-like proteinase]] | ||
| + | * [[SARS-CoV-2_protein_NSP4|NSP4]]: ''Non-structural protein 4''. | ||
| + | * [[SARS-CoV-2 enzyme 3CL-PRO|Proteinase 3CL-PRO]] | ||
| + | * '''''AlphaFold2 Theoretical Model''''' [[SARS-CoV-2_protein_NSP6|NSP6]]: ''Non-structural protein 6''. | ||
| + | * [[SARS-CoV-2_protein_NSP7|NSP7]]: ''Non-structural protein 7''. | ||
| + | * [[SARS-CoV-2_protein_NSP8|NSP8]]: ''Non-structural protein 8''. | ||
| + | * [[SARS-CoV-2_protein_NSP9|NSP9]]: ''Non-structural protein 9''. | ||
| + | * [[SARS-CoV-2_protein_NSP10|NSP10]]: ''Non-structural protein 10''. | ||
| + | * [[SARS-CoV-2 enzyme RdRp|RNA-directed RNA polymerase (RdRp)]] | ||
| + | * [[SARS-CoV-2 enzyme Hel|Helicase (Hel)]]: Multi-functional protein with a zinc-binding domain in N-terminus | ||
| + | * [[SARS-CoV-2 enzyme ExoN|Guanine-N7 methyltransferase (ExoN)]] | ||
| + | * [[SARS-CoV-2 enzyme NendoU|Uridylate-specific endoribonuclease (NendoU)]] | ||
| + | * [[SARS-CoV-2 enzyme 2'-O-MT|2'-O-methyltransferase (2'-O-MT)]]: Methyltransferase that mediates mRNA cap 2'-O-ribose methylation to the 5'-cap structure of viral mRNAs. | ||
| + | * [[SARS-CoV-2_protein_S|Surface glycoprotein (S)]] and [[SARS-CoV-2 protein S priming by furin]] | ||
| + | * [[SARS-CoV-2 protein ORF3a|ORF3a]]: Forms homotetrameric potassium sensitive ion channels (viroporin) and may modulate virus release. | ||
| + | * [[SARS-CoV-2_protein_E|Protein E]]: Plays a central role in virus morphogenesis and assembly. | ||
| + | * '''''AlphaFold2 Theoretical Model''''' [[SARS-CoV-2_protein_M|Protein M]]: Component of the viral envelope. | ||
| + | * [[SARS-CoV-2 protein ORF6|ORF6]]: Could be a determinant of virus virulence. | ||
| + | * [[SARS-CoV-2 protein ORF7a|ORF7a]]: Non-structural protein which is dispensable for virus replication in cell culture. | ||
| + | * [[SARS-CoV-2 protein ORF8|ORF8]]: Open Reading Frame 8. | ||
| + | * '''''AlphaFold2 Theoretical Model''''' [[SARS-CoV-2_protein_N|Protein N]]: Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP). | ||
| + | * '''''AlphaFold2 Theoretical Model''''' [[SARS-CoV-2 protein ORF10|ORF10]]: It is currently unclear whether this region translates into a functional protein. | ||
</StructureSection> | </StructureSection> | ||
| - | == References == | ||
| - | <references/> | ||
Revision as of 18:08, 6 February 2022
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