MAPK/ERK pathway
From Proteopedia
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MAPK/ERK pathway (also known as the Ras-Raf-MEK-ERK pathway) is a chain of proteins in the cell that communicates a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell. | MAPK/ERK pathway (also known as the Ras-Raf-MEK-ERK pathway) is a chain of proteins in the cell that communicates a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell. | ||
| - | * | + | *Cell surface receptors that can activate this pathway via GRB2: |
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| + | [[Epidermal Growth Factor Receptor]] (EGFR; see also [[Epidermal growth factor]]). EGFR belongs to [[Receptor tyrosine kinases]], class I. | ||
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| + | Trk A/B: [[High affinity nerve growth factor receptor]] (TrkA). [[TrkB tyrosine kinase receptor]]. See also [[Neurotrophin]]. | ||
*[[Growth factor receptor-bound proteins]] (GRB) are adaptor proteins. GRBs contain SH2, Ras-associated (RA) and pleckstrin homology (PH) domains. For additional details on GRB10 see [[Grb10 SH2 Domain]]. | *[[Growth factor receptor-bound proteins]] (GRB) are adaptor proteins. GRBs contain SH2, Ras-associated (RA) and pleckstrin homology (PH) domains. For additional details on GRB10 see [[Grb10 SH2 Domain]]. | ||
Revision as of 16:46, 14 February 2022
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