1yx4

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Current revision (08:07, 15 May 2024) (edit) (undo)
 
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==Structure of S5a bound to monoubiquitin provides a model for polyubiquitin recognition==
==Structure of S5a bound to monoubiquitin provides a model for polyubiquitin recognition==
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<StructureSection load='1yx4' size='340' side='right'caption='[[1yx4]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
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<StructureSection load='1yx4' size='340' side='right'caption='[[1yx4]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1yx4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YX4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YX4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1yx4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YX4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YX4 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1d3z|1d3z]], [[1tbe|1tbe]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PSMD4, MCB1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yx4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yx4 OCA], [https://pdbe.org/1yx4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yx4 RCSB], [https://www.ebi.ac.uk/pdbsum/1yx4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yx4 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yx4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yx4 OCA], [https://pdbe.org/1yx4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yx4 RCSB], [https://www.ebi.ac.uk/pdbsum/1yx4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yx4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PSD4_HUMAN PSD4_HUMAN]] Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate.<ref>PMID:12082148</ref> <ref>PMID:21458045</ref>
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[https://www.uniprot.org/uniprot/PSMD4_HUMAN PSMD4_HUMAN] Binds and presumably selects ubiquitin-conjugates for destruction. Displays selectivity for longer polyubiquitin chains. Modulates intestinal fluid secretion.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Walters, K J]]
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[[Category: Walters KJ]]
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[[Category: Wang, Q]]
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[[Category: Wang Q]]
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[[Category: Young, P]]
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[[Category: Young P]]
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[[Category: Hydrolase]]
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[[Category: Polyubiquitin]]
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[[Category: Proteasome]]
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[[Category: S5a]]
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[[Category: Uim]]
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Current revision

Structure of S5a bound to monoubiquitin provides a model for polyubiquitin recognition

PDB ID 1yx4

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