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Introduction

G protein-coupled receptors (GPCRs) are... ^[1]

GPCRs^[2].

Structure overview

Active Site

Figure Legend

Figure Legend

Sub-pocket 1

Sub-pocket 2

Ligand interactions

Agonist

• C48/80
• (R)-zinc

Antagonist

Mechanism Overview

Gi

Gq

Implications for disease and clinical relevance

medicinal drugs^[3][4].

See Also

• G proteins
• GTP-binding protein
• Pharmaceutical Drugs
• Nobel Prizes for 3D Molecular Structure

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References

1. ↑ Cite error: Invalid <ref> tag; no text was provided for refs named Zhang_2006
2. ↑ Millar RP, Newton CL. The year in G protein-coupled receptor research. Mol Endocrinol. 2010 Jan;24(1):261-74. Epub 2009 Dec 17. PMID:20019124 doi:10.1210/me.2009-0473
3. ↑ Overington JP, Al-Lazikani B, Hopkins AL. How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. PMID:17139284 doi:10.1038/nrd2199
4. ↑ Peeters MC, van Westen GJ, Li Q, IJzerman AP. Importance of the extracellular loops in G protein-coupled receptors for ligand recognition and receptor activation. Trends Pharmacol Sci. 2011 Jan;32(1):35-42. PMID:21075459 doi:10.1016/j.tips.2010.10.001

Student contributors

Madeline Beck

Joey Gareis