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Methionine synthase
From Proteopedia
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This is a complex reaction as the product, tetrahydrofolate, is a poor leaving group, thus requiring a "supernucleophile" with a protein-bound B-12 vitamin Cobalamin as the methyl carrier. | This is a complex reaction as the product, tetrahydrofolate, is a poor leaving group, thus requiring a "supernucleophile" with a protein-bound B-12 vitamin Cobalamin as the methyl carrier. | ||
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| - | </StructureSection> | ||
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== Vitamin B-12 == | == Vitamin B-12 == | ||
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== Oxidation States of Cobalamin == | == Oxidation States of Cobalamin == | ||
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| + | Co(I) - active, unstable, high energy | ||
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| + | Co(II) - common oxidation state | ||
== Relevance == | == Relevance == | ||
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Methionine deficiency can result in diseases such as birth abnormalities. | Methionine deficiency can result in diseases such as birth abnormalities. | ||
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== References == | == References == | ||
Revision as of 18:37, 5 April 2022
Methionine synthase
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References
- ↑ Barra L, Fontenelle C, Ermel G, Trautwetter A, Walker GC, Blanco C. Interrelations between glycine betaine catabolism and methionine biosynthesis in Sinorhizobium meliloti strain 102F34. J Bacteriol. 2006 Oct;188(20):7195-204. doi: 10.1128/JB.00208-06. PMID:17015658 doi:http://dx.doi.org/10.1128/JB.00208-06
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