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= Mechanism =
= Mechanism =
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== G-proteins and Signaling ==
 
[[GTP-binding protein| G-proteins]], when paired with a GPCR, assist in signal transduction.<ref name="edward">DOI: 10.1002/pro.3526</ref><ref name="nelson">Nelson, David L. (David Lee), 1942-. (2005). Lehninger principles of biochemistry. New York :W.H. Freeman</ref> G-proteins are heterotrimeric GTPases composed of three subunits: <scene name='90/904324/Heterotrimeric_labeled/3'>α, β, and γ</scene>. The α subunit acts as the main signal mediator and contains a binding site for GDP or GTP, which acts as a biological “switch” to regulate the transmission of a signal from the activated receptor.<ref name="edward"/><ref name="nelson"/> The α subunit will dissociate and can then move in the plane of the membrane from the receptor to bind to downstream effectors to continue signal transmission and ultimately produce a cellular response.<ref name="edward"/><ref name="nelson"/>
[[GTP-binding protein| G-proteins]], when paired with a GPCR, assist in signal transduction.<ref name="edward">DOI: 10.1002/pro.3526</ref><ref name="nelson">Nelson, David L. (David Lee), 1942-. (2005). Lehninger principles of biochemistry. New York :W.H. Freeman</ref> G-proteins are heterotrimeric GTPases composed of three subunits: <scene name='90/904324/Heterotrimeric_labeled/3'>α, β, and γ</scene>. The α subunit acts as the main signal mediator and contains a binding site for GDP or GTP, which acts as a biological “switch” to regulate the transmission of a signal from the activated receptor.<ref name="edward"/><ref name="nelson"/> The α subunit will dissociate and can then move in the plane of the membrane from the receptor to bind to downstream effectors to continue signal transmission and ultimately produce a cellular response.<ref name="edward"/><ref name="nelson"/>

Revision as of 17:40, 18 April 2022

Human Itch G-Coupled Protein Receptors

Cryo-EM structure of Gq coupled MRGPRX2.

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