Journal:Acta Cryst F:S2053230X22007555
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<b>Molecular Tour</b><br> | <b>Molecular Tour</b><br> | ||
| + | Elizabethkingia bacteria are emerging pathogens globally that cause opportunistic and nosocomial infections with up to 40% mortality among the immune-compromised. Elizabethkingia species are in the pipeline of organisms for high throughput structural analysis at the Seattle Structural Genomics Center for Infectious Disease (SSGCID). These efforts include the structure-function analysis of potential therapeutic targets. Glutamyl-tRNA synthetase (GluRS) is essential to the tRNA aminoacylation and is investigated as a bacterial drug target. The SSGCID produced crystallized and determined high-resolution structures of GluRS from Elizabethkingia meningosepticum (EmGluRS) and Elizabethkingia anopheles (EaGluRS). EmGluRS was co-crystallized with glutamate, while EaGluRS is an apo-structure. EmGluRS shares ~97% sequence identity with EaGluRS but less than 39% sequence identity with any other structures in the Protein Data Bank. EmGluRS and EaGluRS have prototypical bacterial GluRS topology. EmGluRS and EaGluRS have similar binding sites and tertiary structures to other bacterial GluRS that are promising drug targets. These structural similarities can be exploited for drug discovery. | ||
<b>References</b><br> | <b>References</b><br> | ||
Revision as of 14:46, 26 July 2022
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