7t6d
From Proteopedia
(Difference between revisions)
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| - | ==== | + | ==CryoEM structure of the YejM/LapB complex== |
| - | <StructureSection load='7t6d' size='340' side='right'caption='[[7t6d]]' scene=''> | + | <StructureSection load='7t6d' size='340' side='right'caption='[[7t6d]], [[Resolution|resolution]] 3.90Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7t6d]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T6D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T6D FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t6d OCA], [https://pdbe.org/7t6d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t6d RCSB], [https://www.ebi.ac.uk/pdbsum/7t6d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t6d ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.9Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LPP:2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL+HEXADECANOATE'>LPP</scene>, <scene name='pdbligand=PGV:(1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL+(11E)-OCTADEC-11-ENOATE'>PGV</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t6d OCA], [https://pdbe.org/7t6d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t6d RCSB], [https://www.ebi.ac.uk/pdbsum/7t6d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t6d ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/LAPB_ECOLI LAPB_ECOLI] Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane.[HAMAP-Rule:MF_00994]<ref>PMID:24266962</ref> <ref>PMID:24722986</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Escherichia coli]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Mi W]] |
| + | [[Category: Shu S]] | ||
Current revision
CryoEM structure of the YejM/LapB complex
<StructureSection load='7t6d' size='340' side='right'caption='7t6d, resolution 3.90Å' scene=>
Structural highlights
| 7t6d is a 4 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. | |
| Method: | Electron Microscopy, Resolution 3.9Å |
| Ligands: | <scene name='pdbligand=LPP:2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL+HEXADECANOATE'>LPP</scene>, <scene name='pdbligand=PGV:(1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL+(11E)-OCTADEC-11-ENOATE'>PGV</scene> |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
LAPB_ECOLI Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane.[HAMAP-Rule:MF_00994][1] [2]
References
- ↑ Mahalakshmi S, Sunayana MR, SaiSree L, Reddy M. yciM is an essential gene required for regulation of lipopolysaccharide synthesis in Escherichia coli. Mol Microbiol. 2014 Jan;91(1):145-57. PMID:24266962 doi:10.1111/mmi.12452
- ↑ Klein G, Kobylak N, Lindner B, Stupak A, Raina S. Assembly of lipopolysaccharide in Escherichia coli requires the essential LapB heat shock protein. J Biol Chem. 2014 May 23;289(21):14829-53. PMID:24722986 doi:10.1074/jbc.M113.539494
Contents |
</StructureSection>
