Journal:Acta Cryst D:S2059798322009755
From Proteopedia
(Difference between revisions)
| Line 6: | Line 6: | ||
Most of the metazoan genes are interspersed with non-coding information, so called introns. A large macromolecular machinery in the nucleus, the spliceosome, removes these introns from pre-mRNA transcripts linking the coding exons, to yield functional genes for translation. | Most of the metazoan genes are interspersed with non-coding information, so called introns. A large macromolecular machinery in the nucleus, the spliceosome, removes these introns from pre-mRNA transcripts linking the coding exons, to yield functional genes for translation. | ||
| - | <scene name='93/931041/Cv/3'>Crystal structure of the human AAR2Δloop-PRPF8RH complex</scene>. | + | <scene name='93/931041/Cv/3'>Crystal structure of the human AAR2Δloop-PRPF8RH complex</scene>. In this and the following scenes: AAR2<sup>Δloop</sup>, orange; PRPF8<sup>RH</sup>, light blue; a flexible loop (labeled Ser3) of AAR2 connecting its two domains, which in AAR2<sup>Δloop</sup> was replaced by three serine residues and another smaller flexible loop between residues 313-321 are labeled. N- and C-termini as well as the β-finger module of PRPF8<sup>RH</sup> are labeled. |
The structure and functional data of the human spliceosomal assembly factor Aar2 in complex with a core spliceosomal domain of the PRPF8 protein indicates a different function of human Aar2 in contrast to the yeast protein. | The structure and functional data of the human spliceosomal assembly factor Aar2 in complex with a core spliceosomal domain of the PRPF8 protein indicates a different function of human Aar2 in contrast to the yeast protein. | ||
Revision as of 07:11, 18 October 2022
| |||||||||||
This page complements a publication in scientific journals and is one of the Proteopedia's Interactive 3D Complement pages. For aditional details please see I3DC.
