Journal:Acta Cryst D:S2059798322009755
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<scene name='93/931041/Cv/4'>Crystal structure of the human AAR2Δloop-PRPF8RH complex</scene>. In this and the following scenes: AAR2<sup>Δloop</sup>, orange; PRPF8<sup>RH</sup>, light blue; a flexible loop (labeled Ser3) of AAR2 connecting its two domains, which in AAR2<sup>Δloop</sup> was replaced by three serine residues and another smaller flexible loop between residues 313-321 are labeled. N- and C-termini as well as the β-finger module of PRPF8<sup>RH</sup> are labeled. | <scene name='93/931041/Cv/4'>Crystal structure of the human AAR2Δloop-PRPF8RH complex</scene>. In this and the following scenes: AAR2<sup>Δloop</sup>, orange; PRPF8<sup>RH</sup>, light blue; a flexible loop (labeled Ser3) of AAR2 connecting its two domains, which in AAR2<sup>Δloop</sup> was replaced by three serine residues and another smaller flexible loop between residues 313-321 are labeled. N- and C-termini as well as the β-finger module of PRPF8<sup>RH</sup> are labeled. | ||
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| + | <scene name='93/931041/Cv/5'>Superposition of the RH domains of human PRPF8 and yeast Prp8p</scene> in complex with human AAR2<sup>Δloop</sup> and yeast Aar2p/PRPF8<sup>JM</sup> (PDB ID [[4i43]]) | ||
The structure and functional data of the human spliceosomal assembly factor Aar2 in complex with a core spliceosomal domain of the PRPF8 protein indicates a different function of human Aar2 in contrast to the yeast protein. | The structure and functional data of the human spliceosomal assembly factor Aar2 in complex with a core spliceosomal domain of the PRPF8 protein indicates a different function of human Aar2 in contrast to the yeast protein. | ||
Revision as of 07:39, 18 October 2022
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