Polycomb proteins

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'''Polycomb group (PcG) proteins''' are determinants of gene silencing and epigenetic memory in higher eukaryotes. The PcG system consists of multimeric repressive protein complexes containing chromatin modifying activities which regulate transcription by modulating chromatin structures. The PcG proteins regulate pathways in cell differentiation, tissue regeneration and cancer cell growth<ref>PMID:27705803</ref>. For the '''B'''-cell-specific '''M'''olony leukemia virus '''I'''nsertion site '''1''' (BMI1) see [[BMI1]].
'''Polycomb group (PcG) proteins''' are determinants of gene silencing and epigenetic memory in higher eukaryotes. The PcG system consists of multimeric repressive protein complexes containing chromatin modifying activities which regulate transcription by modulating chromatin structures. The PcG proteins regulate pathways in cell differentiation, tissue regeneration and cancer cell growth<ref>PMID:27705803</ref>. For the '''B'''-cell-specific '''M'''olony leukemia virus '''I'''nsertion site '''1''' (BMI1) see [[BMI1]].
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*'''Pcgf5''' is required in the differentiation of embryonic stem cells toward neural cells<ref>PMID:29765032</ref>.
See also: [[Polycomb complex protein]].
See also: [[Polycomb complex protein]].

Revision as of 07:28, 22 July 2024

Human polycomb complex protein BMI-1 (olive and dark red) complex with histones (grey, green, yellow, pink, magenta, cyan, gold, red), RING1B/Ubch5C (aqua and orchid)and DNA (blue and gold) PDB code 4r8p

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3D structures of polycomb proteins

Polycomb complex proteins 3D structures


References

  1. ↑ Hauri S, Comoglio F, Seimiya M, Gerstung M, Glatter T, Hansen K, Aebersold R, Paro R, Gstaiger M, Beisel C. A High-Density Map for Navigating the Human Polycomb Complexome. Cell Rep. 2016 Oct 4;17(2):583-595. doi: 10.1016/j.celrep.2016.08.096. PMID:27705803 doi:http://dx.doi.org/10.1016/j.celrep.2016.08.096
  2. ↑ Yao M, Zhou X, Zhou J, Gong S, Hu G, Li J, Huang K, Lai P, Shi G, Hutchins AP, Sun H, Wang H, Yao H. PCGF5 is required for neural differentiation of embryonic stem cells. Nat Commun. 2018 May 15;9(1):1463. doi: 10.1038/s41467-018-03781-0. PMID:29765032 doi:http://dx.doi.org/10.1038/s41467-018-03781-0
  3. ↑ Poynter ST, Kadoch C. Polycomb and trithorax opposition in development and disease. Wiley Interdiscip Rev Dev Biol. 2016 Nov;5(6):659-688. doi: 10.1002/wdev.244., Epub 2016 Sep 1. PMID:27581385 doi:http://dx.doi.org/10.1002/wdev.244

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