3-Hydroxypropionate bicycle

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The 3-Hydroxypropionate bicycle, also known as the 3-Hydroxypropionate pathway, is a process that allows some bacteria to generate 3-Hydroxypropionate utilizing carbon dioxide. In this pathway CO2 is fixed (''i.e.'' incorporated) by the action of two enzymes, [[acetyl-CoA carboxylase]] and [[propionyl-CoA carboxylase]]. See also [[Carbon Fixation]].
The 3-Hydroxypropionate bicycle, also known as the 3-Hydroxypropionate pathway, is a process that allows some bacteria to generate 3-Hydroxypropionate utilizing carbon dioxide. In this pathway CO2 is fixed (''i.e.'' incorporated) by the action of two enzymes, [[acetyl-CoA carboxylase]] and [[propionyl-CoA carboxylase]]. See also [[Carbon Fixation]].
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These enzymes generate <scene name='49/492046/Cv/7'>malonyl-CoA</scene> and (S)-methylmalonyl-CoA, respectively. Malonyl-CoA, in a series of reactions is further split into <scene name='43/430893/Cv/2'>acetyl-CoA</scene> and glyoxylate. Glyoxylate is incorporated into beta-methylmalyl-coA which is then split, again through a series of reactions to release pyruvate as well as acetate, which is used to replenish the cycle.
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These enzymes generate <scene name='49/492046/Cv/7'>malonyl-CoA</scene> and (S)-methylmalonyl-CoA, respectively. Malonyl-CoA, in a series of reactions is further split into <scene name='43/430893/Cv/2'>acetyl-CoA</scene> and <scene name='93/939250/Cv/1'>glyoxylate</scene>. Glyoxylate is incorporated into beta-methylmalyl-CoA which is then split, again through a series of reactions to release pyruvate as well as acetate, which is used to replenish the cycle.
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== References ==
== References ==
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Revision as of 13:17, 6 February 2023

E. coli Acetyl-CoA carboxylase biotinyl domain complex with biotin (PDB code 1bdo)

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References

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