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1l8w

From Proteopedia

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{{STRUCTURE_1l8w| PDB=1l8w | SCENE= }}
{{STRUCTURE_1l8w| PDB=1l8w | SCENE= }}
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'''Crystal Structure of Lyme Disease Variable Surface Antigen VlsE of Borrelia burgdorferi'''
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===Crystal Structure of Lyme Disease Variable Surface Antigen VlsE of Borrelia burgdorferi===
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==Overview==
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VlsE is an outer surface lipoprotein of Borrelia burgdorferi that undergoes antigenic variation through an elaborate gene conversion mechanism and is thought to play a major role in the immune response to the Lyme disease borellia. The crystal structure of recombinant variant protein VlsE1 at 2.3-A resolution reveals that the six variable regions form loop structures that constitute most of the membrane distal surface of VlsE, covering the predominantly alpha-helical, invariant regions of the protein. The surface localization of the variable amino acid segments appears to protect the conserved regions from interaction with antibodies and hence may contribute to immune evasion.
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(as it appears on PubMed at http://www.pubmed.gov), where 11923306 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11923306}}
==About this Structure==
==About this Structure==
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[[Category: Variable surface protein]]
[[Category: Variable surface protein]]
[[Category: Vmp-like sequence]]
[[Category: Vmp-like sequence]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:40:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:58:43 2008''

Revision as of 08:58, 2 July 2008

Image:1l8w.png


PDB ID 1l8w

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1l8w, resolution 2.30Å ()
Non-Standard Residues:
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of Lyme Disease Variable Surface Antigen VlsE of Borrelia burgdorferi

Template:ABSTRACT PUBMED 11923306

About this Structure

1L8W is a Single protein structure of sequence from Borrelia burgdorferi. Full crystallographic information is available from OCA.

Reference

Crystal structure of Lyme disease variable surface antigen VlsE of Borrelia burgdorferi., Eicken C, Sharma V, Klabunde T, Lawrenz MB, Hardham JM, Norris SJ, Sacchettini JC, J Biol Chem. 2002 Jun 14;277(24):21691-6. Epub 2002 Mar 28. PMID:11923306

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