1nmb

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1nmb.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1nmb.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1nmb| PDB=1nmb | SCENE= }}
{{STRUCTURE_1nmb| PDB=1nmb | SCENE= }}
-
'''THE STRUCTURE OF A COMPLEX BETWEEN THE NC10 ANTIBODY AND INFLUENZA VIRUS NEURAMINIDASE AND COMPARISON WITH THE OVERLAPPING BINDING SITE OF THE NC41 ANTIBODY'''
+
===THE STRUCTURE OF A COMPLEX BETWEEN THE NC10 ANTIBODY AND INFLUENZA VIRUS NEURAMINIDASE AND COMPARISON WITH THE OVERLAPPING BINDING SITE OF THE NC41 ANTIBODY===
-
==Overview==
+
<!--
-
BACKGROUND: While it is well known that different antibodies can be produced against a particular antigen, and even against a particular site on an antigen, up until now there have been no structural studies of cross-reacting antibodies of this type. One antibody-antigen complex whose structure is known is that of the influenza virus antigen, neuraminidase, in complex with the NC41 antibody. Another anti-neuraminidase antibody, NC10, binds to an overlapping site on the antigen. The structure of the complex formed by this antibody with neuraminidase is described here and compared with the NC41-containing complex. RESULTS: The crystal structure of the NC10 Fab-neuraminidase complex has been refined to a nominal resolution of 2.5A. Approximately 80% of the binding site of the NC10 antibody on neuraminidase overlaps with that of the NC41 antibody. The epitope residues of neuraminidase are often engaged in quite different interactions with the two antibodies. Although the NC10 and NC41 antibodies have identical amino acid sequences within the first complementarity determining region of their heavy chains, this is not the basis of the cross-reaction. CONCLUSIONS: The capacity of two different proteins to bind to the same target structure on a third protein need not be based on the existence of identical or homologous amino acid sequences within those proteins. As we have demonstrated, amino acid residues on the common target structure may be in quite different chemical environments, and may also adopt different conformations within two protein-protein complexes.
+
The line below this paragraph, {{ABSTRACT_PUBMED_7994573}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 7994573 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_7994573}}
==About this Structure==
==About this Structure==
Line 26: Line 30:
[[Category: Malby, R L.]]
[[Category: Malby, R L.]]
[[Category: Tulip, W R.]]
[[Category: Tulip, W R.]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:42:17 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:05:19 2008''

Revision as of 00:05, 28 July 2008

Image:1nmb.png

Template:STRUCTURE 1nmb

THE STRUCTURE OF A COMPLEX BETWEEN THE NC10 ANTIBODY AND INFLUENZA VIRUS NEURAMINIDASE AND COMPARISON WITH THE OVERLAPPING BINDING SITE OF THE NC41 ANTIBODY

Template:ABSTRACT PUBMED 7994573

About this Structure

1NMB is a Protein complex structure of sequences from Influenza virus a/whale/maine/1/84 isolated from pilot whale (globicephala melaena) and Mus musculus. Full crystallographic information is available from OCA.

Reference

The structure of a complex between the NC10 antibody and influenza virus neuraminidase and comparison with the overlapping binding site of the NC41 antibody., Malby RL, Tulip WR, Harley VR, McKimm-Breschkin JL, Laver WG, Webster RG, Colman PM, Structure. 1994 Aug 15;2(8):733-46. PMID:7994573

Page seeded by OCA on Mon Jul 28 03:05:19 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1nmb"
Personal tools