6sh2
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6sh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sh2 OCA], [https://pdbe.org/6sh2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6sh2 RCSB], [https://www.ebi.ac.uk/pdbsum/6sh2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6sh2 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6sh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sh2 OCA], [https://pdbe.org/6sh2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6sh2 RCSB], [https://www.ebi.ac.uk/pdbsum/6sh2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6sh2 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Function == | ||
| - | [https://www.uniprot.org/uniprot/NEP_HUMAN NEP_HUMAN] Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers.<ref>PMID:2531377</ref> <ref>PMID:15283675</ref> <ref>PMID:20876573</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Current revision
Crystal structure of human neprilysin E584D in complex with C-type natriuretic peptide.
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