Collagenase (non-MMP)
From Proteopedia
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'''Collagenase''' (Col) catalyzes the breaking of peptide bonds in collagen. Col cleaves pro-collagen to create collagen. Some collagenases are part of the [[Matrix metalloproteinase]] family. | '''Collagenase''' (Col) catalyzes the breaking of peptide bonds in collagen. Col cleaves pro-collagen to create collagen. Some collagenases are part of the [[Matrix metalloproteinase]] family. | ||
| - | *Collagenase G recognises and unravels collagen microfibrils into triple helices and unwind them<ref>PMID:21947205</ref>. | + | *'''Collagenase G''' recognises and unravels collagen microfibrils into triple helices and unwind them<ref>PMID:21947205</ref>. |
| + | *'''Collagenase H''' targets collagen III<ref>PMID:23768818</ref>. | ||
== Relevance == | == Relevance == | ||
Current revision
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References
- ↑ Eckhard U, Schonauer E, Nuss D, Brandstetter H. Structure of collagenase G reveals a chew-and-digest mechanism of bacterial collagenolysis. Nat Struct Mol Biol. 2011 Sep 25;18(10):1109-14. doi: 10.1038/nsmb.2127. PMID:21947205 doi:10.1038/nsmb.2127
- ↑ Fujio A, Murayama K, Yamagata Y, Watanabe K, Imura T, Inagaki A, Ohbayashi N, Shima H, Sekiguchi S, Fujimori K, Igarashi K, Ohuchi N, Satomi S, Goto M. Collagenase H is crucial for isolation of rat pancreatic islets. Cell Transplant. 2014;23(10):1187-98. PMID:23768818 doi:10.3727/096368913X668654
- ↑ Eckhard U, Schonauer E, Brandstetter H. Structural basis for activity regulation and substrate preference of clostridial collagenases G, H, and T. J Biol Chem. 2013 May 23. PMID:23703618 doi:10.1074/jbc.M112.448548
