9dpf

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m (Protected "9dpf" [edit=sysop:move=sysop])
Current revision (04:18, 17 October 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9dpf is ON HOLD
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==Crystal structure of TMPRSS11D S368A complexed with its own zymogen activation motif==
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<StructureSection load='9dpf' size='340' side='right'caption='[[9dpf]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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Authors: Fraser, B.J., Dong, A., Ilyassov, O., Seitova, A., Li, Y., Edwards, A., Benard, F., Arrowsmith, C., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9dpf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9DPF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9DPF FirstGlance]. <br>
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Description: Crystal structure of TMPRSS11D S368A complexed with its own zymogen activation motif
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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[[Category: Fraser, B.J]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9dpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9dpf OCA], [https://pdbe.org/9dpf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9dpf RCSB], [https://www.ebi.ac.uk/pdbsum/9dpf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9dpf ProSAT]</span></td></tr>
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[[Category: Structural Genomics Consortium (Sgc)]]
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</table>
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[[Category: Ilyassov, O]]
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== Function ==
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[[Category: Li, Y]]
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[https://www.uniprot.org/uniprot/TM11D_HUMAN TM11D_HUMAN] May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides, cleaving Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently and having an optimum pH of 8.6 with this substrate.<ref>PMID:23536651</ref> <ref>PMID:24227843</ref>
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[[Category: Dong, A]]
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== References ==
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[[Category: Arrowsmith, C]]
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<references/>
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[[Category: Seitova, A]]
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__TOC__
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[[Category: Edwards, A]]
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</StructureSection>
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[[Category: Benard, F]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith C]]
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[[Category: Benard F]]
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[[Category: Dong A]]
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[[Category: Edwards A]]
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[[Category: Fraser BJ]]
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[[Category: Ilyassov O]]
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[[Category: Li Y]]
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[[Category: Seitova A]]

Current revision

Crystal structure of TMPRSS11D S368A complexed with its own zymogen activation motif

PDB ID 9dpf

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OCA

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