9gtv

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Current revision (09:33, 25 December 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9gtv is ON HOLD until Paper Publication
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==Crystal structure of RamR with Tyr59 replaced with para-boronophenylalanine (boronate form)==
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<StructureSection load='9gtv' size='340' side='right'caption='[[9gtv]], [[Resolution|resolution]] 2.78&Aring;' scene=''>
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Authors: Longwitz, L., Brouwer, B., Thunnissen, A.M.W.H., Roelfes, G.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9gtv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9GTV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9GTV FirstGlance]. <br>
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Description: Crystal structure of RamR with Tyr59 replaced with para-boronophenylalanine (boronate form)
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.78&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9gtv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9gtv OCA], [https://pdbe.org/9gtv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9gtv RCSB], [https://www.ebi.ac.uk/pdbsum/9gtv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9gtv ProSAT]</span></td></tr>
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[[Category: Thunnissen, A.M.W.H]]
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</table>
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[[Category: Brouwer, B]]
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== Function ==
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[[Category: Longwitz, L]]
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[https://www.uniprot.org/uniprot/HTHTR_SALTY HTHTR_SALTY] Transcriptional regulator (PubMed:18443112, PubMed:22948865, PubMed:23800819, PubMed:30655545). Represses the transcription of the transcriptional activator RamA and, thereby, leads to repression of the expression of the efflux pump subunits AcrA and AcrB, and TolC (PubMed:18443112, PubMed:22948865, PubMed:23800819, PubMed:30655545). Acts by binding directly to the promoter region of the ramA gene (PubMed:22123696, PubMed:22948865, PubMed:23800819). Promoter binding may be inhibited partially by the small regulatory RNA StyR3, perhaps thereby ensuring a basal level of expression of RamA.[UniProtKB:A0A0H3GJQ8]<ref>PMID:18443112</ref> <ref>PMID:22123696</ref> <ref>PMID:22948865</ref> <ref>PMID:23800819</ref> <ref>PMID:30655545</ref>
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[[Category: Roelfes, G]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
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[[Category: Brouwer B]]
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[[Category: Longwitz L]]
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[[Category: Roelfes G]]
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[[Category: Thunnissen AMWH]]

Current revision

Crystal structure of RamR with Tyr59 replaced with para-boronophenylalanine (boronate form)

PDB ID 9gtv

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OCA

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