9jn9

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Current revision (11:07, 18 June 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9jn9 is ON HOLD until Paper Publication
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==Cryo-EM structure of human SLFN14==
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<StructureSection load='9jn9' size='340' side='right'caption='[[9jn9]], [[Resolution|resolution]] 3.36&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9jn9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9JN9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9JN9 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.36&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9jn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9jn9 OCA], [https://pdbe.org/9jn9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9jn9 RCSB], [https://www.ebi.ac.uk/pdbsum/9jn9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9jn9 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/SLN14_HUMAN SLN14_HUMAN] Autosomal dominant thrombocytopenia with platelet secretion defect. The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/SLN14_HUMAN SLN14_HUMAN] Shows no ribosome-associated and endoribonuclease activities.<ref>PMID:25996083</ref> Displays polysome-associated endoribonuclease activity towards mRNAs and rRNAs (PubMed:25996083). May play a role in RNA surveillance pathways by recognizing stalled ribosomes and triggering endonucleolytic cleavage of aberrant mRNAs (Probable). Cleaves different types of rRNAs and mRNAs in a magnesium- and manganese-dependent and ATP-independent manner (By similarity). Involved in correct maturation of megakaryocytes and especially important for proplatelet extension.[UniProtKB:G1SRW8]<ref>PMID:25996083</ref> <ref>PMID:26769223</ref> <ref>PMID:25996083</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Gao S]]
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[[Category: Jia XD]]
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[[Category: Luo M]]
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[[Category: Wang ZW]]
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[[Category: Yang JY]]
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[[Category: Zhang QF]]

Current revision

Cryo-EM structure of human SLFN14

PDB ID 9jn9

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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