Synthetic nanomaterials from standardized protein blocks
From Proteopedia
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In March, 2024, Huddy ''et al.'' in the team of David Baker (subsequently a [[Nobel_Prizes_for_3D_Molecular_Structure#2020-2029|Nobel Laureate]]) published a wide range of synthetic protein nanostructures self-assembled from standardized, engineered alpha-helical protein "building blocks"<ref name="huddy2024">PMID: 38480887</ref>. The extensively documented report, in ''Nature'', has 32 authors<ref name="huddy2024" />. | In March, 2024, Huddy ''et al.'' in the team of David Baker (subsequently a [[Nobel_Prizes_for_3D_Molecular_Structure#2020-2029|Nobel Laureate]]) published a wide range of synthetic protein nanostructures self-assembled from standardized, engineered alpha-helical protein "building blocks"<ref name="huddy2024">PMID: 38480887</ref>. The extensively documented report, in ''Nature'', has 32 authors<ref name="huddy2024" />. | ||
| - | The breakthrough here is that instead of designing a single "one-off" desired nanostructure, the Baker group has first designed a series of regular building blocks that can be assembled into diverse nanostructures using straightforward geometric principles. These now enable "construction of protein nanomaterials according to ‘back of an envelope’ architectural blueprints"<ref name="huddy2024" />. There are many potential applications, such as drug delivery or catalysis, which remain to be explored | + | The breakthrough here is that instead of designing a single "one-off" desired nanostructure, the Baker group has first designed a series of regular building blocks that can be assembled into diverse nanostructures using straightforward geometric principles. These now enable "construction of protein nanomaterials according to ‘back of an envelope’ architectural blueprints"<ref name="huddy2024" />. There are many potential applications, such as drug delivery or catalysis, which remain to be explored. |
==Building Blocks== | ==Building Blocks== | ||
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| - | In this project, the simplest building blocks consist of anti-parallel alpha helices engineered to be straight and flat, that is ''twistless helix repeat'' (THR) protein blocks. A simple example, THR1, is [[8g9j]], consisting of <scene name='10/1068508/8g9j_flat_square/3'>eight anti-parallel alpha helices with seven turns per helix</scene>. Each helix is amphipathic, that is, hydrophobic on the side contacting other helixes, and hydrophilic on the side facing outwards (not shown). The <scene name='10/1068508/8g9j_flat_square/2'>block surface is designed to have many charges</scene>, making a highly water soluble building block. | + | In this project, the simplest building blocks consist of anti-parallel alpha helices engineered to be straight and flat, that is ''twistless helix repeat'' (THR) protein blocks. A simple example, THR1, is [[8g9j]], consisting of <scene name='10/1068508/8g9j_flat_square/3'>eight anti-parallel alpha helices with seven turns per helix</scene>. Each helix is amphipathic, that is, hydrophobic on the side contacting other helixes, and hydrophilic on the side facing outwards (not shown). The <scene name='10/1068508/8g9j_flat_square/2'>block surface is designed to have many charges</scene>, making a highly water soluble building block. The edges of the block are "capped" with sufficient charges to prevent these blocks from binding to each other. |
==Related Work== | ==Related Work== | ||
Revision as of 02:43, 4 January 2025
This page is under construction. This notice will be removed when it is ready. Eric Martz 21:20, 23 December 2024 (UTC) |
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References
- ↑ 1.0 1.1 1.2 Huddy TF, Hsia Y, Kibler RD, Xu J, Bethel N, Nagarajan D, Redler R, Leung PJY, Weidle C, Courbet A, Yang EC, Bera AK, Coudray N, Calise SJ, Davila-Hernandez FA, Han HL, Carr KD, Li Z, McHugh R, Reggiano G, Kang A, Sankaran B, Dickinson MS, Coventry B, Brunette TJ, Liu Y, Dauparas J, Borst AJ, Ekiert D, Kollman JM, Bhabha G, Baker D. Blueprinting extendable nanomaterials with standardized protein blocks. Nature. 2024 Mar;627(8005):898-904. PMID:38480887 doi:10.1038/s41586-024-07188-4
- ↑ Wang S, Favor A, Kibler R, Lubner J, Borst AJ, Coudray N, Redler RL, Chiang HT, Sheffler W, Hsia Y, Li Z, Ekiert DC, Bhabha G, Pozzo LD, Baker D. Bond-centric modular design of protein assemblies. bioRxiv [Preprint]. 2024 Oct 12:2024.10.11.617872. PMID:39416012 doi:10.1101/2024.10.11.617872
