Synthetic nanomaterials from standardized protein blocks
From Proteopedia
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==Assemblies== | ==Assemblies== | ||
| - | Building blocks were designed with precise angles, and with specific points of attachment between blocks. Most self-assembled into the predicted assemblies<ref>The assemblies shown can be downloaded as PDB files from supplementary materials of Huddy ''et al,'', 2024.</ref> | + | Building blocks were designed with precise angles, and with specific points of attachment between blocks. Most self-assembled into the predicted assemblies<ref>The assemblies shown can be downloaded as PDB files from supplementary materials of Huddy ''et al,'', 2024.</ref>. The size of the final assembly can be controlled by the number of helices and their lengths in the building blocks. Examples of assemblies include: |
===Flat Assemblies=== | ===Flat Assemblies=== | ||
* <scene name='10/1068508/Triangle/1'>Triangle, three blocks, one sequence</scene> (120_C3_A_design, branch 60°). | * <scene name='10/1068508/Triangle/1'>Triangle, three blocks, one sequence</scene> (120_C3_A_design, branch 60°). | ||
Revision as of 17:30, 5 January 2025
This page is under construction. This notice will be removed when it is ready. Eric Martz 21:20, 23 December 2024 (UTC) |
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See Also
- Related work from the Baker group includes Bond-centric modular design of protein assemblies by Wang et al., 2024[5].
- Metal-Ligand Polyhedra
References
- ↑ 1.0 1.1 1.2 1.3 Huddy TF, Hsia Y, Kibler RD, Xu J, Bethel N, Nagarajan D, Redler R, Leung PJY, Weidle C, Courbet A, Yang EC, Bera AK, Coudray N, Calise SJ, Davila-Hernandez FA, Han HL, Carr KD, Li Z, McHugh R, Reggiano G, Kang A, Sankaran B, Dickinson MS, Coventry B, Brunette TJ, Liu Y, Dauparas J, Borst AJ, Ekiert D, Kollman JM, Bhabha G, Baker D. Blueprinting extendable nanomaterials with standardized protein blocks. Nature. 2024 Mar;627(8005):898-904. PMID:38480887 doi:10.1038/s41586-024-07188-4
- ↑ An amino-terminal histidine tag was not resolved in the electron density map of 8g9j, and thus is missing in the structure depicted.
- ↑ The five modules shown are from the following assemblies that can be downloaded as PDB files from supplementary materials of Huddy et al,, 2024: 90° from strut_C6_16. Branch from TT_rail+_tie+. Curve from R20A. Handshake 90° from cage_O4_32. Handshake obtuse angle from cage_I3_8.
- ↑ The assemblies shown can be downloaded as PDB files from supplementary materials of Huddy et al,, 2024.
- ↑ Wang S, Favor A, Kibler R, Lubner J, Borst AJ, Coudray N, Redler RL, Chiang HT, Sheffler W, Hsia Y, Li Z, Ekiert DC, Bhabha G, Pozzo LD, Baker D. Bond-centric modular design of protein assemblies. bioRxiv [Preprint]. 2024 Oct 12:2024.10.11.617872. PMID:39416012 doi:10.1101/2024.10.11.617872
