9otp
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Human glutamine synthetase R298A decamer under turnover conditions== | |
| - | + | <StructureSection load='9otp' size='340' side='right'caption='[[9otp]], [[Resolution|resolution]] 1.95Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9otp]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9OTP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9OTP FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 1.95Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9otp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9otp OCA], [https://pdbe.org/9otp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9otp RCSB], [https://www.ebi.ac.uk/pdbsum/9otp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9otp ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Greene | + | == Disease == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/GLNA_HUMAN GLNA_HUMAN] Defects in GLUL are the cause of congenital systemic glutamine deficiency (CSGD) [MIM:[https://omim.org/entry/610015 610015]. CSGD is a rare developmental disorder with severe brain malformation resulting in multi-organ failure and neonatal death. Glutamine is largely absent from affected patients serum, urine and cerebrospinal fluid.<ref>PMID:16267323</ref> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GLNA_HUMAN GLNA_HUMAN] This enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts.<ref>PMID:18662667</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Fraser JS]] | ||
| + | [[Category: Greene ER]] | ||
| + | [[Category: Kollman JM]] | ||
| + | [[Category: Muniz RS]] | ||
Current revision
Human glutamine synthetase R298A decamer under turnover conditions
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