3c2i
From Proteopedia
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===The Crystal Structure of Methyl-CpG Binding Domain of Human MeCP2 in Complex with a Methylated DNA Sequence from BDNF=== | ===The Crystal Structure of Methyl-CpG Binding Domain of Human MeCP2 in Complex with a Methylated DNA Sequence from BDNF=== | ||
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| - | ==Disease== | ||
| - | Known disease associated with this structure: Angelman syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=300005 300005]], Encephalopathy, neonatal severe OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=300005 300005]], Mental retardation, X-linked, Lubs type OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=300005 300005]], Mental retardation, X-linked, syndromic 13 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=300005 300005]], Rett syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=300005 300005]], Rett syndrome, preserved speech variant OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=300005 300005]], Autism, susceptibility to, X-linked-3 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=300005 300005]] | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[3c2i]] is a 3 chain structure of [[Methyl CpG Binding Protein 2]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C2I OCA]. | |
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| + | ==See Also== | ||
| + | *[[Methyl CpG Binding Protein 2|Methyl CpG Binding Protein 2]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:018313390</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Bird, A P.]] | [[Category: Bird, A P.]] | ||
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[[Category: Schmiedeberg, L.]] | [[Category: Schmiedeberg, L.]] | ||
[[Category: Walkinshaw, M D.]] | [[Category: Walkinshaw, M D.]] | ||
| - | [[Category: Alternative splicing]] | ||
[[Category: Asx-st-motif]] | [[Category: Asx-st-motif]] | ||
| - | [[Category: Chromosomal rearrangement]] | ||
[[Category: Disease mutation]] | [[Category: Disease mutation]] | ||
[[Category: Dna-binding]] | [[Category: Dna-binding]] | ||
[[Category: Nucleus]] | [[Category: Nucleus]] | ||
[[Category: Phosphoprotein]] | [[Category: Phosphoprotein]] | ||
| - | [[Category: Polymorphism]] | ||
[[Category: Protein-methylated dna complex]] | [[Category: Protein-methylated dna complex]] | ||
[[Category: Repressor]] | [[Category: Repressor]] | ||
[[Category: Transcription regulator]] | [[Category: Transcription regulator]] | ||
[[Category: Water mediated recognition]] | [[Category: Water mediated recognition]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 11:31:25 2009'' | ||
Revision as of 15:39, 26 July 2012
Contents |
The Crystal Structure of Methyl-CpG Binding Domain of Human MeCP2 in Complex with a Methylated DNA Sequence from BDNF
Template:ABSTRACT PUBMED 18313390
About this Structure
3c2i is a 3 chain structure of Methyl CpG Binding Protein 2 with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Ho KL, McNae IW, Schmiedeberg L, Klose RJ, Bird AP, Walkinshaw MD. MeCP2 binding to DNA depends upon hydration at methyl-CpG. Mol Cell. 2008 Feb 29;29(4):525-31. PMID:18313390 doi:10.1016/j.molcel.2007.12.028
