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Neuraminidase

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#REDIRECT [[Avian Influenza Neuraminidase, Tamiflu and Relenza]]
#REDIRECT [[Avian Influenza Neuraminidase, Tamiflu and Relenza]]
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==3D structures of Neuraminidase==
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===Neuraminidase===
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[[2ya4]], [[2w20]], [[2vvz]] – SpNANA catalytic domain – Streptococcus pneumoniae<br />
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[[3h71]] - SpNANA catalytic domain precursor<br />
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[[2vw0]], [[2vw1]], [[2vw2]] - SpNANB<br />
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[[2xzi]], [[2xzj]], [[2xzk]], [[2xcy]] – NANA – Aspergillus fumigatus<br />
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[[2w68]] – VcNANA sialic acid binding domain – Vibrio cholerae<br />
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[[1w0o]], [[1kit]]– VcNANA<br />
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[[1snt]], [[1so7]] – hNeu2 - human<br />
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[[2f24]], [[2f26]], [[2f28]] – hNeu2 (mutant) <br />
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[[1eur]] - MvNANA residues 43-407 – Micromonospora viridifaciens<br />
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[[1euu]] - MvNANA residues 47-647<br />
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[[1wcq]], [[1w8n]], [[1w8o]], [[2hu0]], [[2hu4]] – MvNANA residues 47-647 (mutant) <br />
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[[3sil]] – StNANA (mutant) – Salmonella typhimurium
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Binary complexes
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[[3h72]] - SpNANA catalytic domain precursor + sialic derivative<br />
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[[3h73]] - SpNANA catalytic domain precursor + sialic acid analog<br />
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[[2ya5]] - SpNANA catalytic domain + sialic acid<br />
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[[2ya7]], [[2ya8]] - SpNANA catalytic domain + inhibitor<br />
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[[2ya6]] - SpNANA catalytic domain + sialic acid analog<br />
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[[2jkb]] - SpNANB residues 30-697 + sialic acid analog<br />
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[[1w0p]] – VcNANA + sialic derivative<br />
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[[2f0z]], [[2f10]], [[2f11]], [[2f12]], [[2f13]] – hNeu2 + inhibitor<br />
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[[2f25]], [[2f27]], [[2f29]] - hNeu2 (mutant) + sialic acid analog<br />
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[[1vcu]] - hNeu2 + sialic acid analog<br />
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[[1eus]] - MvNANA residues 43-407 + neuraminic acid derivative<br />
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[[2bzd]] - MvNANA residues 47-647 (mutant) + galactose<br />
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[[1eut]] - MvNANA residues 47-647 + galactose<br />
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[[2ber]] - MvNANA residues 47-647 (mutant) + sialic derivative<br />
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[[1dil]], [[1dim]] – StNANA + inhibitor<br />
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[[2sim]], [[2sil]] - StNANA + neuraminic acid derivative<br />
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===Influenza virus neuraminidase===
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[[3nss]], [[3k36]], [[3beq]], [[3cye]], [[2cml]], [[2b8h]], [[2ht5]], [[1v0z]], [[1nn2]] – IvNANA residues 82-469 – Influenza virus<br />
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[[3k38]] – IvNANA (mutant) <br />
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[[2ht5]] – IvNAN N8 residues 82-469<br />
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[[2htv]] - IvNAN N4 residues 82-469<br />
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[[2hty]] - IvNAN N1 residues 82-469<br />
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[[3nn9]], [[4nn9]], [[5nn9]], [[6nn9]] - IvNAN N9 residues 82-469<br />
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[[7nn9]] - IvNAN N9 Tern<br />
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[[2qwa]] - IvNAN N9 Tern (mutant)
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Binary complexes
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[[3o9j]], [[3o9k]], [[2c4a]], [[2c4l]], [[1w1x]], [[1w20]], [[1w21]], [[1nsb]], [[1nsc]], [[1nsd]] – IvNANA + sialic derivative<br />
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[[3k37]], [[3b7e]], [[1vcj]], [[1l7f]], [[1f8c]], [[1f8d]], [[1f8e]], [[1a4g]], [[1a4q]], [[1b9t]], [[1b9v]], [[1b9s]], [[1inf]], [[1ing]], [[1inh]], [[1ivb]], [[1ivc]], [[1ivd]], [[1ive]], [[1ivf]], [[1ivg]] – IvNANA + inhibitor<br />
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[[1f8b]], [[1inv]], [[1inw]], [[1inx]], [[1iny]] – IvNANA + sialic acid analog<br />
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[[2ht7]], [[2ht8]], [[2htq]], [[2htu]] – IvNAN N8 + inhibitor<br />
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[[2htr]] – IvNAN N8 + sialic acid analog<br />
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[[2htw]] - IvNAN N4 + sialic acid analog<br />
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[[2bat]] – IvNAN N2 + sialic acid<br />
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[[1nna]], [[1nnb]] - IvNAN N9 + neuraminic acid derivative<br />
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[[1xoe]], [[1xog]] - IvNAN N9 Tern + inhibitor<br />
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[[2qwb]] - IvNAN N9 Tern (mutant) + sialic derivative<br />
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[[2qwc]], [[2qwd]], [[2qwe]] - IvNAN N9 Tern (mutant) + sialic acid analog<br />
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[[1mwe]] - IvNAN N9 Tern + sialic acid<br />
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[[1bji]], [[1nnc]] - IvNAN N9 Tern + sialic acid analog<br />
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[[2qwf]], [[2qwg]], [[2qwh]], [[2qwi]], [[2qwj]], [[2qwk]] - IvNAN N9 Tern (mutant) + inhibitor<br />
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[[1nma]], [[1nmb]] - IvNAN N9 Tern + mFAB heavy+light chain – mouse<br />
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[[1nca]], [[1ncb]], [[1ncc]], [[1ncd]] - IvNAN N9 + mFAB heavy+light chain<br />
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[[3k39]], [[3k3a]], [[3ckz]], [[3cl0]], [[3cl2]], [[1l7g]], [[1l7h]] - IvNANA (mutant) + inhibitor<br />
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[[2aep]], [[2aeq]] – IvNANA + mFAB heavy+light chain
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===Endo-neuraminidase===
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[[3gvl]] - ENANA<br />
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[[3gvf]], [[3gvk]] – ENANA (mutant) – Enterobacteria phage K1F
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===Pseudaminidase===
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[[2w38]] – PNANA – Pseudomonas aeruginosa
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===Trans-sialidase===
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[[2sli]], [[1sli]], [[3sli]] – lTS + inhibitor – leech

Revision as of 08:57, 11 May 2011

  1. REDIRECT Avian Influenza Neuraminidase, Tamiflu and Relenza

Contents

3D structures of Neuraminidase

Neuraminidase

2ya4, 2w20, 2vvz – SpNANA catalytic domain – Streptococcus pneumoniae
3h71 - SpNANA catalytic domain precursor
2vw0, 2vw1, 2vw2 - SpNANB
2xzi, 2xzj, 2xzk, 2xcy – NANA – Aspergillus fumigatus
2w68 – VcNANA sialic acid binding domain – Vibrio cholerae
1w0o, 1kit– VcNANA
1snt, 1so7 – hNeu2 - human
2f24, 2f26, 2f28 – hNeu2 (mutant)
1eur - MvNANA residues 43-407 – Micromonospora viridifaciens
1euu - MvNANA residues 47-647
1wcq, 1w8n, 1w8o, 2hu0, 2hu4 – MvNANA residues 47-647 (mutant)
3sil – StNANA (mutant) – Salmonella typhimurium

Binary complexes

3h72 - SpNANA catalytic domain precursor + sialic derivative
3h73 - SpNANA catalytic domain precursor + sialic acid analog
2ya5 - SpNANA catalytic domain + sialic acid
2ya7, 2ya8 - SpNANA catalytic domain + inhibitor
2ya6 - SpNANA catalytic domain + sialic acid analog
2jkb - SpNANB residues 30-697 + sialic acid analog
1w0p – VcNANA + sialic derivative
2f0z, 2f10, 2f11, 2f12, 2f13 – hNeu2 + inhibitor
2f25, 2f27, 2f29 - hNeu2 (mutant) + sialic acid analog
1vcu - hNeu2 + sialic acid analog
1eus - MvNANA residues 43-407 + neuraminic acid derivative
2bzd - MvNANA residues 47-647 (mutant) + galactose
1eut - MvNANA residues 47-647 + galactose
2ber - MvNANA residues 47-647 (mutant) + sialic derivative
1dil, 1dim – StNANA + inhibitor
2sim, 2sil - StNANA + neuraminic acid derivative

Influenza virus neuraminidase

3nss, 3k36, 3beq, 3cye, 2cml, 2b8h, 2ht5, 1v0z, 1nn2 – IvNANA residues 82-469 – Influenza virus
3k38 – IvNANA (mutant)
2ht5 – IvNAN N8 residues 82-469
2htv - IvNAN N4 residues 82-469
2hty - IvNAN N1 residues 82-469
3nn9, 4nn9, 5nn9, 6nn9 - IvNAN N9 residues 82-469
7nn9 - IvNAN N9 Tern
2qwa - IvNAN N9 Tern (mutant)

Binary complexes

3o9j, 3o9k, 2c4a, 2c4l, 1w1x, 1w20, 1w21, 1nsb, 1nsc, 1nsd – IvNANA + sialic derivative
3k37, 3b7e, 1vcj, 1l7f, 1f8c, 1f8d, 1f8e, 1a4g, 1a4q, 1b9t, 1b9v, 1b9s, 1inf, 1ing, 1inh, 1ivb, 1ivc, 1ivd, 1ive, 1ivf, 1ivg – IvNANA + inhibitor
1f8b, 1inv, 1inw, 1inx, 1iny – IvNANA + sialic acid analog
2ht7, 2ht8, 2htq, 2htu – IvNAN N8 + inhibitor
2htr – IvNAN N8 + sialic acid analog
2htw - IvNAN N4 + sialic acid analog
2bat – IvNAN N2 + sialic acid
1nna, 1nnb - IvNAN N9 + neuraminic acid derivative
1xoe, 1xog - IvNAN N9 Tern + inhibitor
2qwb - IvNAN N9 Tern (mutant) + sialic derivative
2qwc, 2qwd, 2qwe - IvNAN N9 Tern (mutant) + sialic acid analog
1mwe - IvNAN N9 Tern + sialic acid
1bji, 1nnc - IvNAN N9 Tern + sialic acid analog
2qwf, 2qwg, 2qwh, 2qwi, 2qwj, 2qwk - IvNAN N9 Tern (mutant) + inhibitor
1nma, 1nmb - IvNAN N9 Tern + mFAB heavy+light chain – mouse
1nca, 1ncb, 1ncc, 1ncd - IvNAN N9 + mFAB heavy+light chain
3k39, 3k3a, 3ckz, 3cl0, 3cl2, 1l7g, 1l7h - IvNANA (mutant) + inhibitor
2aep, 2aeq – IvNANA + mFAB heavy+light chain

Endo-neuraminidase

3gvl - ENANA
3gvf, 3gvk – ENANA (mutant) – Enterobacteria phage K1F

Pseudaminidase

2w38 – PNANA – Pseudomonas aeruginosa

Trans-sialidase

2sli, 1sli, 3sli – lTS + inhibitor – leech

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Eran Hodis

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