This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Pioglitazone
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | <applet load="" size="480" color="" frame="true" spin="on" Scene ="User:David_Canner/Sandbox_crestor/Rosu/1" align="right" caption="Rosuvastatin, also known as Crestor"/> | ||
===Better Known as: Actos=== | ===Better Known as: Actos=== | ||
* Marketed By: Takeda Pharmaceuticals<br /> | * Marketed By: Takeda Pharmaceuticals<br /> | ||
| Line 8: | Line 7: | ||
* Why You Should Care: It is the best selling drug to treat Diabetes and is the 10th best selling drug in the United States. | * Why You Should Care: It is the best selling drug to treat Diabetes and is the 10th best selling drug in the United States. | ||
* The following is a list of Pharmacokinetic Parameters. See: [[Pharmaceutical Drugs]] for more information | * The following is a list of Pharmacokinetic Parameters. See: [[Pharmaceutical Drugs]] for more information | ||
| - | ===Mechanism of Action=== | ||
| - | |||
| - | ===Pharmacokinetics=== | ||
| - | |||
| - | {| class="wikitable" border="1" width="40%" style="text-align:center" | ||
| - | |- | ||
| - | ! colspan="6" align="center"| Glitazone Comparison | ||
| - | |- | ||
| - | ! Parameter | ||
| - | ! [[Pioglitazone]] (Actos) | ||
| - | ! [[Rosiglitazone]] (Avandia) | ||
| - | |||
| - | |- | ||
| - | ! [[Pharmaceutical_Drugs#Tmax|T<sub>max</sub>]] (hr) | ||
| - | ! | ||
| - | ! | ||
| - | |||
| - | |- | ||
| - | ! [[Pharmaceutical_Drugs#Cmax|C<sub>max</sub>]] (ng/ml) | ||
| - | ! | ||
| - | ! | ||
| - | |- | ||
| - | ! [[Pharmaceutical_Drugs#Bioavailability_.28F.29|Bioavailability]] (%) | ||
| - | ! | ||
| - | ! | ||
| - | |- | ||
| - | ! [[Pharmaceutical_Drugs#Protein_Binding|Protein Binding]] (%) | ||
| - | ! 99 | ||
| - | ! 99 | ||
| - | |- | ||
| - | ! [[Pharmaceutical_Drugs#Half_Life_.28T1.2F2.29|T<sub>1/2</sub>]] (hr) | ||
| - | ! 3-7 | ||
| - | ! 3-4 | ||
| - | |- | ||
| - | ! [[Pharmaceutical_Drugs#Area_Under_the_Curve_.28AUC.29|AUC]] (ng/ml/hr) | ||
| - | ! | ||
| - | ! | ||
| - | |- | ||
| - | ! [[Pharmaceutical_Drugs#Inhibitory_Concentration_.28IC50.29|IC<sub>50</sub>]] (nM) | ||
| - | ! | ||
| - | ! | ||
| - | |- | ||
| - | ! Equivalent Dosage (mg) | ||
| - | ! | ||
| - | ! | ||
| - | |- | ||
| - | ! Metabolism | ||
| - | ! Hepatic <br/>(CYP2C8) | ||
| - | ! Hepatic <br/>(CYP2C8) | ||
| - | |} | ||
| - | |||
| - | ===Effectiveness and Side Effects=== | ||
| - | ====Effectiveness==== | ||
| - | |||
| - | ====Side Effects==== | ||
| - | |||
| - | ===Interesting Facts=== | ||
| - | |||
| - | ===The Jist=== | ||
===References=== | ===References=== | ||
Revision as of 08:50, 11 November 2010
Better Known as: Actos
- Marketed By: Takeda Pharmaceuticals
- Major Indication: Hypoglycemia & Type 2 Diabetes
- Drug Class: PPAR-γ Activator - Thiazolidinedione (Glitazones)
- Date of FDA Approval (Patent Expiration): 1999 (2011)
- 2009 Sales: $2.4 Billion [1]
- Why You Should Care: It is the best selling drug to treat Diabetes and is the 10th best selling drug in the United States.
- The following is a list of Pharmacokinetic Parameters. See: Pharmaceutical Drugs for more information
References
