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Tositumomab

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(New page: ===Pharmacokinetics=== {| class="wikitable" border="1" width="52%" style="text-align:center" |- ! colspan="12" align="center"| Anti-CD20 Monoclonal Antibody [[Pharmaceutical_Drugs#Pharmac...)
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! [[Pharmaceutical_Drugs#Inhibitory_Concentration_.28IC50.29|IC<sub>50</sub>]] (nM)
! Tositumomab
! Tositumomab
! Ofatumumab
! Ofatumumab
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! Ibritumomab
! Ibritumomab
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! Dosage (mg)
! Tositumomab
! Tositumomab
! Ofatumumab
! Ofatumumab
! Rituximab
! Rituximab
! Ibritumomab
! Ibritumomab
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|-
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! Metabolism
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! Tositumomab
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! Ofatumumab
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! Rituximab
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! Ibritumomab
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Revision as of 06:38, 6 December 2010

Pharmacokinetics

Anti-CD20 Monoclonal Antibody Pharmacokinetics
Parameter Tositumomab Ofatumumab Rituximab Ibritumomab
Tmax (hr) Tositumomab Ofatumumab Rituximab Ibritumomab
Cmax (ng/ml) Tositumomab Ofatumumab Rituximab Ibritumomab
Bioavailability (%) Tositumomab Ofatumumab Rituximab Ibritumomab
Protein Binding (%) Tositumomab Ofatumumab Rituximab Ibritumomab
T1/2 (hr) Tositumomab Ofatumumab Rituximab Ibritumomab
AUC (ng/ml/hr) Tositumomab Ofatumumab Rituximab Ibritumomab
Clearance (L/h) Tositumomab Ofatumumab Rituximab Ibritumomab
IC50 (nM) Tositumomab Ofatumumab Rituximab Ibritumomab
Dosage (mg) Tositumomab Ofatumumab Rituximab Ibritumomab
Metabolism Tositumomab Ofatumumab Rituximab Ibritumomab

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