Tositumomab

From Proteopedia

proteopedia linkproteopedia link

Revision as of 07:04, 6 December 2010 (edit) David Canner (Talk | contribs) ← Previous diff		Revision as of 07:16, 6 December 2010 (edit) (undo) David Canner (Talk | contribs) Next diff →
Line 19:		Line 19:
	! Tositumomab		! Tositumomab
	! 167000		! 167000
-	! Rituximab	+	! 205800
	! Ibritumomab		! Ibritumomab
	|-		|-
Line 37:		Line 37:
	! 64.8		! 64.8
	! 68		! 68
-	! Rituximab	+	! 206
	! Ibritumomab		! Ibritumomab
	|-		|-
Line 49:		Line 49:
	! .078		! .078
	! .017		! .017
-	! Rituximab	+	! .009
	! Ibritumomab		! Ibritumomab
	|-		|-
Line 58:		Line 58:
	! Ibritumomab		! Ibritumomab
	|-		|-
-	! Dosage (mg)	+	! Dosage
	! Tositumomab		! Tositumomab
-	! 500 (4th Infusion)	+	! 500 mg (4th Infusion)
-	! Rituximab	+	! 325 mg/m<sup>2</sup> (4th Infusion)
	! Ibritumomab		! Ibritumomab
	|-		|-

---

Revision as of 07:16, 6 December 2010

Pharmacokinetics

Anti-CD20 Monoclonal Antibody Pharmacokinetics [1]
Parameter	Tositumomab	Ofatumumab	Rituximab	Ibritumomab
Tmax (hr)	Tositumomab	7.6	Rituximab	Ibritumomab
Cmax (ng/ml)	Tositumomab	167000	205800	Ibritumomab
Bioavailability (%)	Tositumomab	Ofatumumab	Rituximab	Ibritumomab
Protein Binding (%)	Tositumomab	Ofatumumab	Rituximab	Ibritumomab
T1/2 (hr)	64.8	68	206	Ibritumomab
AUC (ng/ml/hr)	Tositumomab	32939000	Rituximab	Ibritumomab
Clearance (L/h)	.078	.017	.009	Ibritumomab
IC50 (nM)	Tositumomab	Ofatumumab	Rituximab	Ibritumomab
Dosage	Tositumomab	500 mg (4th Infusion)	325 mg/m2 (4th Infusion)	Ibritumomab
Metabolism	Tositumomab	Ofatumumab	Rituximab	Ibritumomab