This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


Lapatinib

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 18: Line 18:
! 115
! 115
! 24.6
! 24.6
-
! Sorafenib (Nexavar)
+
! 460
|-
|-
! [[Pharmaceutical_Drugs#Bioavailability_.28F.29|Bioavailability]] (%)
! [[Pharmaceutical_Drugs#Bioavailability_.28F.29|Bioavailability]] (%)
Line 33: Line 33:
! 9.6
! 9.6
! 83
! 83
-
! Sorafenib (Nexavar)
+
! 29
|-
|-
! [[Pharmaceutical_Drugs#Area_Under_the_Curve_.28AUC.29|AUC]] (ng/ml/hr)
! [[Pharmaceutical_Drugs#Area_Under_the_Curve_.28AUC.29|AUC]] (ng/ml/hr)
! 1429
! 1429
! 1921
! 1921
-
! Sorafenib (Nexavar)
+
! 11040
|-
|-
! [[Pharmaceutical_Drugs#Inhibitory_Concentration_.28IC50.29|IC<sub>50</sub>]] (nM)
! [[Pharmaceutical_Drugs#Inhibitory_Concentration_.28IC50.29|IC<sub>50</sub>]] (nM)
Line 48: Line 48:
! 100
! 100
! 50
! 50
-
! Sorafenib (Nexavar)
+
! 50
|-
|-
! Metabolism
! Metabolism

Revision as of 08:03, 6 December 2010

Pharmacokinetics

Tyrosine Kinase Inhibitor Pharmacokinetics [1][2]
Parameter Lapatinib (Tykerb) Sunitinib (Sutent) Sorafenib (Nexavar)
Tmax (hr) 4 Sunitinib (Sutent) Sorafenib (Nexavar)
Cmax (ng/ml) 115 24.6 460
Bioavailability (%) Lapatinib (Tykerb) Sunitinib (Sutent) Sorafenib (Nexavar)
Protein Binding (%) Lapatinib (Tykerb) Sunitinib (Sutent) Sorafenib (Nexavar)
T1/2 (hr) 9.6 83 29
AUC (ng/ml/hr) 1429 1921 11040
IC50 (nM) Lapatinib (Tykerb) Sunitinib (Sutent) Sorafenib (Nexavar)
Dosage (mg) 100 50 50
Metabolism Lapatinib (Tykerb) Sunitinib (Sutent) Sorafenib (Nexavar)

Proteopedia Page Contributors and Editors (what is this?)

David Canner, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Lapatinib"
Personal tools