NSAID Pharmacokinetics

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(New page: {| class="wikitable" border="1" width="40%" style="text-align:center" |- ! colspan="6" align="center"| Glitazone Pharmacokinetics Comp...)
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|-
|-
! [[Pharmaceutical_Drugs#Tmax|T<sub>max</sub>]] (hr)
! [[Pharmaceutical_Drugs#Tmax|T<sub>max</sub>]] (hr)
-
! 1.8
+
! Ibuprofen (Advil)
-
! 1
+
! Naproxen (Aleve)
-
 
+
! Flurbiprofen (Ansaid)
 +
! Acetylsalicylic Acid (Aspirin)
 +
! Valdecoxib (Bextra)
 +
! Celecoxib (Celebrex)
 +
! Sulindac (Clinoril)
 +
! Oxaprozin (Daypro)
 +
! Piroxicam (Feldene)
 +
! Nabumetone (Relafen)
 +
! Acetaminophen (Paracetamol)
 +
! Mefanamic Acid (Ponstel)
 +
! Ketorolac (Toradol)
 +
! Rofecoxib (Vioxx)
 +
! Diclofenac (Voltaren)
|-
|-
! [[Pharmaceutical_Drugs#Cmax|C<sub>max</sub>]] (ng/ml)
! [[Pharmaceutical_Drugs#Cmax|C<sub>max</sub>]] (ng/ml)
-
! 617
+
! Ibuprofen (Advil)
-
! 361
+
! Naproxen (Aleve)
 +
! Flurbiprofen (Ansaid)
 +
! Acetylsalicylic Acid (Aspirin)
 +
! Valdecoxib (Bextra)
 +
! Celecoxib (Celebrex)
 +
! Sulindac (Clinoril)
 +
! Oxaprozin (Daypro)
 +
! Piroxicam (Feldene)
 +
! Nabumetone (Relafen)
 +
! Acetaminophen (Paracetamol)
 +
! Mefanamic Acid (Ponstel)
 +
! Ketorolac (Toradol)
 +
! Rofecoxib (Vioxx)
 +
! Diclofenac (Voltaren)
|-
|-
! [[Pharmaceutical_Drugs#Bioavailability_.28F.29|Bioavailability]] (%)
! [[Pharmaceutical_Drugs#Bioavailability_.28F.29|Bioavailability]] (%)
-
! 83
+
! Ibuprofen (Advil)
-
! 99
+
! Naproxen (Aleve)
 +
! Flurbiprofen (Ansaid)
 +
! Acetylsalicylic Acid (Aspirin)
 +
! Valdecoxib (Bextra)
 +
! Celecoxib (Celebrex)
 +
! Sulindac (Clinoril)
 +
! Oxaprozin (Daypro)
 +
! Piroxicam (Feldene)
 +
! Nabumetone (Relafen)
 +
! Acetaminophen (Paracetamol)
 +
! Mefanamic Acid (Ponstel)
 +
! Ketorolac (Toradol)
 +
! Rofecoxib (Vioxx)
 +
! Diclofenac (Voltaren)
|-
|-
! [[Pharmaceutical_Drugs#Protein_Binding|Protein Binding]] (%)
! [[Pharmaceutical_Drugs#Protein_Binding|Protein Binding]] (%)
-
! 99
+
! Ibuprofen (Advil)
-
! 99
+
! Naproxen (Aleve)
 +
! Flurbiprofen (Ansaid)
 +
! Acetylsalicylic Acid (Aspirin)
 +
! Valdecoxib (Bextra)
 +
! Celecoxib (Celebrex)
 +
! Sulindac (Clinoril)
 +
! Oxaprozin (Daypro)
 +
! Piroxicam (Feldene)
 +
! Nabumetone (Relafen)
 +
! Acetaminophen (Paracetamol)
 +
! Mefanamic Acid (Ponstel)
 +
! Ketorolac (Toradol)
 +
! Rofecoxib (Vioxx)
 +
! Diclofenac (Voltaren)
|-
|-
! [[Pharmaceutical_Drugs#Half_Life_.28T1.2F2.29|T<sub>1/2</sub>]] (hr)
! [[Pharmaceutical_Drugs#Half_Life_.28T1.2F2.29|T<sub>1/2</sub>]] (hr)
-
! 3-8
+
! Ibuprofen (Advil)
-
! 3-4
+
! Naproxen (Aleve)
 +
! Flurbiprofen (Ansaid)
 +
! Acetylsalicylic Acid (Aspirin)
 +
! Valdecoxib (Bextra)
 +
! Celecoxib (Celebrex)
 +
! Sulindac (Clinoril)
 +
! Oxaprozin (Daypro)
 +
! Piroxicam (Feldene)
 +
! Nabumetone (Relafen)
 +
! Acetaminophen (Paracetamol)
 +
! Mefanamic Acid (Ponstel)
 +
! Ketorolac (Toradol)
 +
! Rofecoxib (Vioxx)
 +
! Diclofenac (Voltaren)
|-
|-
! [[Pharmaceutical_Drugs#Area_Under_the_Curve_.28AUC.29|AUC]] (ng/ml/hr)
! [[Pharmaceutical_Drugs#Area_Under_the_Curve_.28AUC.29|AUC]] (ng/ml/hr)
-
! 6244
+
! Ibuprofen (Advil)
-
! 2024
+
! Naproxen (Aleve)
 +
! Flurbiprofen (Ansaid)
 +
! Acetylsalicylic Acid (Aspirin)
 +
! Valdecoxib (Bextra)
 +
! Celecoxib (Celebrex)
 +
! Sulindac (Clinoril)
 +
! Oxaprozin (Daypro)
 +
! Piroxicam (Feldene)
 +
! Nabumetone (Relafen)
 +
! Acetaminophen (Paracetamol)
 +
! Mefanamic Acid (Ponstel)
 +
! Ketorolac (Toradol)
 +
! Rofecoxib (Vioxx)
 +
! Diclofenac (Voltaren)
|-
|-
! [[Pharmaceutical_Drugs#Inhibitory_Concentration_.28IC50.29|IC<sub>50</sub>]] (nM)
! [[Pharmaceutical_Drugs#Inhibitory_Concentration_.28IC50.29|IC<sub>50</sub>]] (nM)
-
! 360
+
! Ibuprofen (Advil)
-
! 10
+
! Naproxen (Aleve)
 +
! Flurbiprofen (Ansaid)
 +
! Acetylsalicylic Acid (Aspirin)
 +
! Valdecoxib (Bextra)
 +
! Celecoxib (Celebrex)
 +
! Sulindac (Clinoril)
 +
! Oxaprozin (Daypro)
 +
! Piroxicam (Feldene)
 +
! Nabumetone (Relafen)
 +
! Acetaminophen (Paracetamol)
 +
! Mefanamic Acid (Ponstel)
 +
! Ketorolac (Toradol)
 +
! Rofecoxib (Vioxx)
 +
! Diclofenac (Voltaren)
|-
|-
! Equivalent Dosage (mg)
! Equivalent Dosage (mg)
-
! 30
+
! Ibuprofen (Advil)
-
! 4
+
! Naproxen (Aleve)
 +
! Flurbiprofen (Ansaid)
 +
! Acetylsalicylic Acid (Aspirin)
 +
! Valdecoxib (Bextra)
 +
! Celecoxib (Celebrex)
 +
! Sulindac (Clinoril)
 +
! Oxaprozin (Daypro)
 +
! Piroxicam (Feldene)
 +
! Nabumetone (Relafen)
 +
! Acetaminophen (Paracetamol)
 +
! Mefanamic Acid (Ponstel)
 +
! Ketorolac (Toradol)
 +
! Rofecoxib (Vioxx)
 +
! Diclofenac (Voltaren)
|-
|-
! Metabolism
! Metabolism
-
! Hepatic <br/>(CYP2C8)
+
! Ibuprofen (Advil)
-
! Hepatic <br/>(CYP2C8)
+
! Naproxen (Aleve)
 +
! Flurbiprofen (Ansaid)
 +
! Acetylsalicylic Acid (Aspirin)
 +
! Valdecoxib (Bextra)
 +
! Celecoxib (Celebrex)
 +
! Sulindac (Clinoril)
 +
! Oxaprozin (Daypro)
 +
! Piroxicam (Feldene)
 +
! Nabumetone (Relafen)
 +
! Acetaminophen (Paracetamol)
 +
! Mefanamic Acid (Ponstel)
 +
! Ketorolac (Toradol)
 +
! Rofecoxib (Vioxx)
 +
! Diclofenac (Voltaren)
|}
|}

Revision as of 17:33, 6 December 2010

Glitazone Pharmacokinetics Comparison at Equivalent Dosages [1][2][3][4]
Parameter Pioglitazone (Actos) Rosiglitazone (Avandia)
Tmax (hr) Ibuprofen (Advil) Naproxen (Aleve) Flurbiprofen (Ansaid) Acetylsalicylic Acid (Aspirin) Valdecoxib (Bextra) Celecoxib (Celebrex) Sulindac (Clinoril) Oxaprozin (Daypro) Piroxicam (Feldene) Nabumetone (Relafen) Acetaminophen (Paracetamol) Mefanamic Acid (Ponstel) Ketorolac (Toradol) Rofecoxib (Vioxx) Diclofenac (Voltaren)
Cmax (ng/ml) Ibuprofen (Advil) Naproxen (Aleve) Flurbiprofen (Ansaid) Acetylsalicylic Acid (Aspirin) Valdecoxib (Bextra) Celecoxib (Celebrex) Sulindac (Clinoril) Oxaprozin (Daypro) Piroxicam (Feldene) Nabumetone (Relafen) Acetaminophen (Paracetamol) Mefanamic Acid (Ponstel) Ketorolac (Toradol) Rofecoxib (Vioxx) Diclofenac (Voltaren)
Bioavailability (%) Ibuprofen (Advil) Naproxen (Aleve) Flurbiprofen (Ansaid) Acetylsalicylic Acid (Aspirin) Valdecoxib (Bextra) Celecoxib (Celebrex) Sulindac (Clinoril) Oxaprozin (Daypro) Piroxicam (Feldene) Nabumetone (Relafen) Acetaminophen (Paracetamol) Mefanamic Acid (Ponstel) Ketorolac (Toradol) Rofecoxib (Vioxx) Diclofenac (Voltaren)
Protein Binding (%) Ibuprofen (Advil) Naproxen (Aleve) Flurbiprofen (Ansaid) Acetylsalicylic Acid (Aspirin) Valdecoxib (Bextra) Celecoxib (Celebrex) Sulindac (Clinoril) Oxaprozin (Daypro) Piroxicam (Feldene) Nabumetone (Relafen) Acetaminophen (Paracetamol) Mefanamic Acid (Ponstel) Ketorolac (Toradol) Rofecoxib (Vioxx) Diclofenac (Voltaren)
T1/2 (hr) Ibuprofen (Advil) Naproxen (Aleve) Flurbiprofen (Ansaid) Acetylsalicylic Acid (Aspirin) Valdecoxib (Bextra) Celecoxib (Celebrex) Sulindac (Clinoril) Oxaprozin (Daypro) Piroxicam (Feldene) Nabumetone (Relafen) Acetaminophen (Paracetamol) Mefanamic Acid (Ponstel) Ketorolac (Toradol) Rofecoxib (Vioxx) Diclofenac (Voltaren)
AUC (ng/ml/hr) Ibuprofen (Advil) Naproxen (Aleve) Flurbiprofen (Ansaid) Acetylsalicylic Acid (Aspirin) Valdecoxib (Bextra) Celecoxib (Celebrex) Sulindac (Clinoril) Oxaprozin (Daypro) Piroxicam (Feldene) Nabumetone (Relafen) Acetaminophen (Paracetamol) Mefanamic Acid (Ponstel) Ketorolac (Toradol) Rofecoxib (Vioxx) Diclofenac (Voltaren)
IC50 (nM) Ibuprofen (Advil) Naproxen (Aleve) Flurbiprofen (Ansaid) Acetylsalicylic Acid (Aspirin) Valdecoxib (Bextra) Celecoxib (Celebrex) Sulindac (Clinoril) Oxaprozin (Daypro) Piroxicam (Feldene) Nabumetone (Relafen) Acetaminophen (Paracetamol) Mefanamic Acid (Ponstel) Ketorolac (Toradol) Rofecoxib (Vioxx) Diclofenac (Voltaren)
Equivalent Dosage (mg) Ibuprofen (Advil) Naproxen (Aleve) Flurbiprofen (Ansaid) Acetylsalicylic Acid (Aspirin) Valdecoxib (Bextra) Celecoxib (Celebrex) Sulindac (Clinoril) Oxaprozin (Daypro) Piroxicam (Feldene) Nabumetone (Relafen) Acetaminophen (Paracetamol) Mefanamic Acid (Ponstel) Ketorolac (Toradol) Rofecoxib (Vioxx) Diclofenac (Voltaren)
Metabolism Ibuprofen (Advil) Naproxen (Aleve) Flurbiprofen (Ansaid) Acetylsalicylic Acid (Aspirin) Valdecoxib (Bextra) Celecoxib (Celebrex) Sulindac (Clinoril) Oxaprozin (Daypro) Piroxicam (Feldene) Nabumetone (Relafen) Acetaminophen (Paracetamol) Mefanamic Acid (Ponstel) Ketorolac (Toradol) Rofecoxib (Vioxx) Diclofenac (Voltaren)

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