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Amantadine

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===Pharmacokinetics===
===Pharmacokinetics===
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! colspan="7" align="center"| M2 Proton Channel Inhibitor [[Pharmaceutical_Drugs#Pharmacokinetics_Translated|Pharmacokinetics]]<ref>PMID:3662473</ref><ref>PMID:17156962</ref>
! colspan="7" align="center"| M2 Proton Channel Inhibitor [[Pharmaceutical_Drugs#Pharmacokinetics_Translated|Pharmacokinetics]]<ref>PMID:3662473</ref><ref>PMID:17156962</ref>

Revision as of 12:14, 7 December 2010

Amantadine, also known as Symmetrel

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Better Known as: Symmetrel

  • Marketed By: N/A
  • Major Indication: Influenza Infection
  • Drug Class: M2 Proton Channel Inhibitor
  • Date of FDA Approval): 1966
  • 1994 Sales: N/A
  • Importance: One of the the first treatments approved by the FDA and the first approved for treatment of Influenza Infections. Nearly 100% of influenza viruses had developed resistance to rimantadine, and it is no longer recommended as a treatment for the flu. Interestingly, in 1969 it was also discovered that Amantadine helped reduce the symptoms of Parkinson's Disease.
  • The following is a list of Pharmacokinetic Parameters. See: Pharmaceutical Drugs for more information

Mechanism of Action

Pharmacokinetics

M2 Proton Channel Inhibitor Pharmacokinetics[1][2]
Parameter Rimantadine Amantadine
Tmax (hr) 4.3 2.5
Cmax (ng/ml) 310 402
Bioavailability (%) >90 >90
Protein Binding (%) 40 67
T1/2 (hr) 27.7 ~15
AUC (ng/ml/hr) 11917 5420
Dosage (mg) 100 100
Metabolism Negligible Negligible

References

  1. ↑ Anderson EL, Van Voris LP, Bartram J, Hoffman HE, Belshe RB. Pharmacokinetics of a single dose of rimantadine in young adults and children. Antimicrob Agents Chemother. 1987 Jul;31(7):1140-2. PMID:3662473
  2. ↑ Wang P, Liang YZ, Chen BM, Zhou N, Yi LZ, Yu Y, Yi ZB. Quantitative determination of amantadine in human plasma by liquid chromatography-mass spectrometry and the application in a bioequivalence study. J Pharm Biomed Anal. 2007 Mar 12;43(4):1519-25. Epub 2006 Dec 6. PMID:17156962 doi:10.1016/j.jpba.2006.10.044


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