3fre

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Revision as of 09:41, 26 December 2010

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Template:STRUCTURE 3fre

Contents 1 S. aureus DHFR complexed with NADPH and TMP 2 About this Structure 3 See Also 4 Reference

S. aureus DHFR complexed with NADPH and TMP

Template:ABSTRACT PUBMED 19211577

About this Structure

3fre is a 1 chain structure of Dihydrofolate reductase with sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

See Also

• Dihydrofolate reductase

Reference

• Oefner C, Bandera M, Haldimann A, Laue H, Schulz H, Mukhija S, Parisi S, Weiss L, Lociuro S, Dale GE. Increased hydrophobic interactions of iclaprim with Staphylococcus aureus dihydrofolate reductase are responsible for the increase in affinity and antibacterial activity. J Antimicrob Chemother. 2009 Apr;63(4):687-98. Epub 2009 Feb 11. PMID:19211577 doi:10.1093/jac/dkp024