Sandbox Reserved 347

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Renin is an aspartyl protease. <ref name= "Structure">PMID:2666611</ref>
Renin is an aspartyl protease. <ref name= "Structure">PMID:2666611</ref>
[[Image:Man pic.png|thumb|left|caption]]
[[Image:Man pic.png|thumb|left|caption]]
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<Structure load='2iko' size='500' frame='true' align='right' caption='Insert caption here' scene='Sandbox_Reserved_347/Ligand/1' />
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<scene name='Sandbox_Reserved_347/Ligand/1'>TextToBeDisplayed</scene>
==Function==
==Function==
Renin plays a key role in the Renin-Angiotension sysmtem (RAS). This system is responsible for the control of blood pressure and salt balances in mammals.
Renin plays a key role in the Renin-Angiotension sysmtem (RAS). This system is responsible for the control of blood pressure and salt balances in mammals.

Revision as of 00:13, 4 March 2011

This Sandbox is Reserved from January 10, 2010, through April 10, 2011 for use in BCMB 307-Proteins course taught by Andrea Gorrell at the University of Northern British Columbia, Prince George, BC, Canada.
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
  • Click the 3D button (when editing, above the wikitext box) to insert Jmol.
  • show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
  • Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing

Contents

Introduction

PDB ID 2iko

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2iko, resolution 1.90Å ()
Ligands:
Gene: REN (Homo sapiens)
Activity: Renin, with EC number 3.4.23.15
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



Renin (pronounced /ˈriːnɨn/ REE-nin), also known as angiotensinogenase is an enzyme that participates in the body's renin-angiotensin system (RAS) that mediates extracellular volume (i.e., that of the blood plasma, lymph and interstitial fluid), and arterial vasoconstriction.
Thus, it regulates the body's mean arterial blood pressure. [1]

Biochemistry

Renin is an aspartyl protease. [2]

caption
caption

Insert caption here

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Function

Renin plays a key role in the Renin-Angiotension sysmtem (RAS). This system is responsible for the control of blood pressure and salt balances in mammals.

Ligand site

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References

  1. ↑ Akahane K, Umeyama H, Nakagawa S, Moriguchi I, Hirose S, Iizuka K, Murakami K. Three-dimensional structure of human renin. Hypertension. 1985 Jan-Feb;7(1):3-12. PMID:3884499
  2. ↑ Inagami T. Structure and function of renin. J Hypertens Suppl. 1989 Apr;7(2):S3-8. PMID:2666611
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