Chaperonin

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== 3D Structures of Chaperonin ==
== 3D Structures of Chaperonin ==
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===Group I===
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Large subunit
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[[3m6c]] – MtGroEL1 apical domain – Mycobacterium tuberculosis<BR />
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[[1sjp]] – MtGroEL2 residues 42-539<BR />
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[[3fbh]], [[2eu1]], [[1j4z]], [[1kpo]], [[1oel]], [[1grl]] – EcGroEL (mutant)]] - Escherichia coli<BR />
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[[3e76]], [[2nwc]], [[1xck]], [[1ss8]] – EcGroEL<BR />
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[[3c9v]], [[3cau]] – EcGroEL – Cryo EM<BR />
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[[2c7e]], [[1gr5]] - EcGroEL (mutant) – Cryo EM<BR />
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[[1kp8]] - EcGroEL (mutant) + ATP<BR />
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[[1sx3]] - EcGroEL + ATP<BR />
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[[1sx4]] - EcGroEL + ADP<BR />
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[[1mnf]] – EcGroEL + polypeptide<BR />
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[[2cgt]] – EcGroEL + capsid assbly protein GP31 – EM<BR />
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[[1fy9]], [[1fya]], [[1kid]] – EcGroEL apical domain (mutant) <BR />
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[[1srv]] – TtCPN60 apical domain]] - Thermus thermophilus<BR />
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[[1iok]] – CPN60 – Paracoccus denitrificans
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Small subunit
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[[3nx6]] – GroES residues 40-134 (mutant) – Xanthomonas oryzae<BR />
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[[1wnr]] – TtCPN10 residues 1-94<BR />
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[[1p3h]], [[1hx5]] – MtCPN10<BR />
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[[1p82]], [[1p83]] - MtCPN10 residues 1-25]] - NMR<BR />
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Large + small subunit
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[[1svt]], [[1pcq]] - EcGroEL + GroES<BR />
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[[1pf9]], [[1aon]] - EcGroEL + GroES + ADP<BR />
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[[2c7c]], [[2c7d]] - EcGroEL + GroES – Cryo EM<BR />
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[[1gru]] - EcGroEL + GroES + ATP + ADP – Cryo EM<BR />
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[[1we3]] – TtCPN60 + CPN10<BR />
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[[1wf4]] - TtCPN60 + CPN10 + ADP
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===Group II===
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[[3izh]], [[3izi]], [[3izj]], [[3izk]], [[3izl]], [[3izm]], [[3izn]], [[3los]], [[3iyf]] – MmCPN – Methanococcus maripaludis – EM<BR />
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[[3kfb]], [[3kfe]], [[3kfk]] – MmCPN<BR />
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[[1q2v]], [[1q3r]] – TkCPN α subunit (mutant) – Thermococcus KS-1<BR />
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[[1q3q]] - TkCPN α subunit (mutant) + AMP-PNP<BR />
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[[1q3s]] - TkCPN α subunit (mutant) + ADP
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CCT
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[[2xsm]] – bCPN CCT – bovine<BR />
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[[3iyg]] - bCPN CCT – Cryo EM<BR />
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[[3ktt]] - bCPN CCT β subunit – Cryo EM<BR />
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[[1gml]], [[1gn1]] - CPN CCT γ subunit apical domain – mouse
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Hsp33
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[[3m7m]], [[1hw7]] – EcCPN Hsp33 N-terminal<BR />
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[[1xjh]] - EcCPN Hsp33 C terminal - NMR<BR />
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[[1vq0]] - CPN Hsp33 – Thermotoga maritime<BR />
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[[1vzy]] - CPN Hsp33 (mutant) – Bacillus subtilis
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Thermosome
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[[1a6d]] - TaTherm α+β subunits– Thermoplasma acidophilum<BR />
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[[1a6e]] - TaTherm α+β subunits + ADP<BR />
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[[1ass]], [[1asx]] - TaTherm α apical domain<BR />
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[[1e0r]] – TaTherm β apical domain
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[[3ko1]] – Therm – Acidianus tengchongensis
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Revision as of 08:03, 21 April 2011

Crystal Structure of Chaperonin, 1pcq
Crystal Structure of Chaperonin, 1pcq

Template:STRUCTURE 1pcq

Chaperonin (CPN) are oligomeric proteins which mediate the folding of polypeptide chains. Group I CPNs are found in bacteria, chloroplasts and mitochondria. They include the most characterized GroEL/GroES complex from Escherichia coli and CPN60/CPN10 from Thermus thermophilus. The larger subunit (GroEL, CPN60) contains 3 domains. The apical domain is the one which binds the substrate. Group II CPNs are found in eukaryotic cytosol and archaea. Thermosome is a CPN complex found in archaea. CCT is a CPN complex found in eukarya.

Contents

3D Structures of Chaperonin

Group I

   Large subunit

3m6c – MtGroEL1 apical domain – Mycobacterium tuberculosis
1sjp – MtGroEL2 residues 42-539
3fbh, 2eu1, 1j4z, 1kpo, 1oel, 1grl – EcGroEL (mutant)]] - Escherichia coli
3e76, 2nwc, 1xck, 1ss8 – EcGroEL
3c9v, 3cau – EcGroEL – Cryo EM
2c7e, 1gr5 - EcGroEL (mutant) – Cryo EM
1kp8 - EcGroEL (mutant) + ATP
1sx3 - EcGroEL + ATP
1sx4 - EcGroEL + ADP
1mnf – EcGroEL + polypeptide
2cgt – EcGroEL + capsid assbly protein GP31 – EM
1fy9, 1fya, 1kid – EcGroEL apical domain (mutant)
1srv – TtCPN60 apical domain]] - Thermus thermophilus
1iok – CPN60 – Paracoccus denitrificans 

         Small subunit

3nx6 – GroES residues 40-134 (mutant) – Xanthomonas oryzae
1wnr – TtCPN10 residues 1-94
1p3h, 1hx5 – MtCPN10
1p82, 1p83 - MtCPN10 residues 1-25]] - NMR

         Large + small subunit

1svt, 1pcq - EcGroEL + GroES
1pf9, 1aon - EcGroEL + GroES + ADP
2c7c, 2c7d - EcGroEL + GroES – Cryo EM
1gru - EcGroEL + GroES + ATP + ADP – Cryo EM
1we3 – TtCPN60 + CPN10
1wf4 - TtCPN60 + CPN10 + ADP

Group II

3izh, 3izi, 3izj, 3izk, 3izl, 3izm, 3izn, 3los, 3iyf – MmCPN – Methanococcus maripaludis – EM
3kfb, 3kfe, 3kfk – MmCPN
1q2v, 1q3r – TkCPN α subunit (mutant) – Thermococcus KS-1
1q3q - TkCPN α subunit (mutant) + AMP-PNP
1q3s - TkCPN α subunit (mutant) + ADP 

    CCT

2xsm – bCPN CCT – bovine
3iyg - bCPN CCT – Cryo EM
3ktt - bCPN CCT β subunit – Cryo EM
1gml, 1gn1 - CPN CCT γ subunit apical domain – mouse 

     Hsp33

3m7m, 1hw7 – EcCPN Hsp33 N-terminal
1xjh - EcCPN Hsp33 C terminal - NMR
1vq0 - CPN Hsp33 – Thermotoga maritime
1vzy - CPN Hsp33 (mutant) – Bacillus subtilis 

      Thermosome

1a6d - TaTherm α+β subunits– Thermoplasma acidophilum
1a6e - TaTherm α+β subunits + ADP
1ass, 1asx - TaTherm α apical domain
1e0r – TaTherm β apical domain 3ko1 – Therm – Acidianus tengchongensis





[Category:Topic Page]]

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