Neuraminidase
From Proteopedia
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| - | [[Image:3nss. | + | [[Image:3nss.jpg|left|200px|thumb|Crystal Structure of Cadherin, [[3nss]]]] |
{{STRUCTURE_3nss| PDB=3nss | SIZE=300| SCENE= |right|CAPTION=Glycosylated Influenza virus neuraminidase complex with calcium and acetate, [[3nss]] }} | {{STRUCTURE_3nss| PDB=3nss | SIZE=300| SCENE= |right|CAPTION=Glycosylated Influenza virus neuraminidase complex with calcium and acetate, [[3nss]] }} | ||
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[[3sil]] – StNANA (mutant) – ''Salmonella typhimurium'' | [[3sil]] – StNANA (mutant) – ''Salmonella typhimurium'' | ||
| - | + | ===Binary complexes of Neuraminidase=== | |
[[3h72]] - SpNANA catalytic domain precursor + sialic derivative<br /> | [[3h72]] - SpNANA catalytic domain precursor + sialic derivative<br /> | ||
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[[2qwa]] - IvNAN N9 Tern (mutant) | [[2qwa]] - IvNAN N9 Tern (mutant) | ||
| - | + | ===Binary complexes of Influenza virus neuraminidase=== | |
[[3o9j]], [[3o9k]], [[2c4a]], [[2c4l]], [[1w1x]], [[1w20]], [[1w21]], [[1nsb]], [[1nsc]], [[1nsd]] – IvNANA + sialic derivative<br /> | [[3o9j]], [[3o9k]], [[2c4a]], [[2c4l]], [[1w1x]], [[1w20]], [[1w21]], [[1nsb]], [[1nsc]], [[1nsd]] – IvNANA + sialic derivative<br /> | ||
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[[2qwf]], [[2qwg]], [[2qwh]], [[2qwi]], [[2qwj]], [[2qwk]] - IvNAN N9 Tern (mutant) + inhibitor<br /> | [[2qwf]], [[2qwg]], [[2qwh]], [[2qwi]], [[2qwj]], [[2qwk]] - IvNAN N9 Tern (mutant) + inhibitor<br /> | ||
[[1nma]], [[1nmb]] - IvNAN N9 Tern + mFAB heavy+light chain – mouse<br /> | [[1nma]], [[1nmb]] - IvNAN N9 Tern + mFAB heavy+light chain – mouse<br /> | ||
| + | [[1a14]] - IvNAN + mFAB heavy+light chain<br /> | ||
[[1nca]], [[1ncb]], [[1ncc]], [[1ncd]] - IvNAN N9 + mFAB heavy+light chain<br /> | [[1nca]], [[1ncb]], [[1ncc]], [[1ncd]] - IvNAN N9 + mFAB heavy+light chain<br /> | ||
[[3k39]], [[3k3a]], [[3ckz]], [[3cl0]], [[3cl2]], [[1l7g]], [[1l7h]] - IvNANA (mutant) + inhibitor<br /> | [[3k39]], [[3k3a]], [[3ckz]], [[3cl0]], [[3cl2]], [[1l7g]], [[1l7h]] - IvNANA (mutant) + inhibitor<br /> | ||
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===Endo-neuraminidase=== | ===Endo-neuraminidase=== | ||
| - | [[ | + | [[3gvf]], [[3gvk]], [[3gvj]] – ENANA (mutant) residues 246-910 – Enterobacteria phage K1F<br /> |
| - | [[ | + | [[3gvl]], [[3ju4]] – ENANA residues 246-910<br /> |
| + | [[3gw6]] – ENANA residues 790-1064<br /> | ||
===Pseudaminidase=== | ===Pseudaminidase=== | ||
Revision as of 10:42, 16 June 2011
Neuraminidase (NAN) cleave the glycosidic bonds of neuraminic acid. The viral NAN is a drug target for prevention of influenza.
Contents |
See also Avian Influenza Neuraminidase, Tamiflu and Relenza
3D structures of Neuraminidase
Update June 2011
Neuraminidase
2ya4, 2w20, 2vvz – SpNANA catalytic domain – Streptococcus pneumoniae
3h71 - SpNANA catalytic domain precursor
2vw0, 2vw1, 2vw2 - SpNANB
2xzi, 2xzj, 2xzk, 2xcy – NANA – Aspergillus fumigatus
2w68 – VcNANA sialic acid binding domain – Vibrio cholerae
1w0o, 1kit– VcNANA
1snt, 1so7 – hNeu2 - human
2f24, 2f26, 2f28 – hNeu2 (mutant)
1eur - MvNANA residues 43-407 – Micromonospora viridifaciens
1euu - MvNANA residues 47-647
1wcq, 1w8n, 1w8o, 2hu0, 2hu4 – MvNANA residues 47-647 (mutant)
3sil – StNANA (mutant) – Salmonella typhimurium
Binary complexes of Neuraminidase
3h72 - SpNANA catalytic domain precursor + sialic derivative
3h73 - SpNANA catalytic domain precursor + sialic acid analog
2ya5 - SpNANA catalytic domain + sialic acid
2ya7, 2ya8 - SpNANA catalytic domain + inhibitor
2ya6 - SpNANA catalytic domain + sialic acid analog
2jkb - SpNANB residues 30-697 + sialic acid analog
1w0p – VcNANA + sialic derivative
2f0z, 2f10, 2f11, 2f12, 2f13 – hNeu2 + inhibitor
2f25, 2f27, 2f29 - hNeu2 (mutant) + sialic acid analog
1vcu - hNeu2 + sialic acid analog
1eus - MvNANA residues 43-407 + neuraminic acid derivative
2bzd - MvNANA residues 47-647 (mutant) + galactose
1eut - MvNANA residues 47-647 + galactose
2ber - MvNANA residues 47-647 (mutant) + sialic derivative
1dil, 1dim – StNANA + inhibitor
2sim, 2sil - StNANA + neuraminic acid derivative
Influenza virus neuraminidase
3nss, 3k36, 3beq, 3cye, 2cml, 2b8h, 2ht5, 1v0z, 1nn2 – IvNANA residues 82-469 – Influenza virus
3k38 – IvNANA (mutant)
2ht5 – IvNAN N8 residues 82-469
2htv - IvNAN N4 residues 82-469
2hty - IvNAN N1 residues 82-469
3nn9, 4nn9, 5nn9, 6nn9 - IvNAN N9 residues 82-469
7nn9 - IvNAN N9 Tern
2qwa - IvNAN N9 Tern (mutant)
Binary complexes of Influenza virus neuraminidase
3o9j, 3o9k, 2c4a, 2c4l, 1w1x, 1w20, 1w21, 1nsb, 1nsc, 1nsd – IvNANA + sialic derivative
3k37, 3b7e, 1vcj, 1l7f, 1f8c, 1f8d, 1f8e, 1a4g, 1a4q, 1b9t, 1b9v, 1b9s, 1inf, 1ing, 1inh, 1ivb, 1ivc, 1ivd, 1ive, 1ivf, 1ivg – IvNANA + inhibitor
1f8b, 1inv, 1inw, 1inx, 1iny – IvNANA + sialic acid analog
2ht7, 2ht8, 2htq, 2htu – IvNAN N8 + inhibitor
2htr – IvNAN N8 + sialic acid analog
2htw - IvNAN N4 + sialic acid analog
2bat – IvNAN N2 + sialic acid
1nna, 1nnb - IvNAN N9 + neuraminic acid derivative
1xoe, 1xog - IvNAN N9 Tern + inhibitor
2qwb - IvNAN N9 Tern (mutant) + sialic derivative
2qwc, 2qwd, 2qwe - IvNAN N9 Tern (mutant) + sialic acid analog
1mwe - IvNAN N9 Tern + sialic acid
1bji, 1nnc - IvNAN N9 Tern + sialic acid analog
2qwf, 2qwg, 2qwh, 2qwi, 2qwj, 2qwk - IvNAN N9 Tern (mutant) + inhibitor
1nma, 1nmb - IvNAN N9 Tern + mFAB heavy+light chain – mouse
1a14 - IvNAN + mFAB heavy+light chain
1nca, 1ncb, 1ncc, 1ncd - IvNAN N9 + mFAB heavy+light chain
3k39, 3k3a, 3ckz, 3cl0, 3cl2, 1l7g, 1l7h - IvNANA (mutant) + inhibitor
2aep, 2aeq – IvNANA + mFAB heavy+light chain
Endo-neuraminidase
3gvf, 3gvk, 3gvj – ENANA (mutant) residues 246-910 – Enterobacteria phage K1F
3gvl, 3ju4 – ENANA residues 246-910
3gw6 – ENANA residues 790-1064
Pseudaminidase
2w38 – PNANA – Pseudomonas aeruginosa
Trans-sialidase
2sli, 1sli, 3sli – lTS + inhibitor – leech
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, Eran Hodis
