G protein-coupled receptor
From Proteopedia
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| - | [[G protein-coupled receptor|G protein-coupled receptors]], often abbreviated GPCRs, are an abundant superamily of proteins also known as [[G protein-coupled receptor|seven-transmembrane domain receptors]], [[G protein-coupled receptor|7TM receptors]], [[G protein-coupled receptor|heptahelical receptors]], [[G protein-coupled receptor|serpentine receptor]], and [[G protein-coupled receptor|G protein-linked receptors (GPLRs)]]. [[G protein-coupled receptor|G protein-coupled receptors] are cell surface signalling proteins involved in many physiological functions and in multiple diseases. they are also the target of the majority of all modern medicinal drugs <ref name="howmany">PMID: 17139284</ref><ref name="pharmtrends">PMID: 21075459</ref> . | + | [[G protein-coupled receptor|G protein-coupled receptors]], often abbreviated GPCRs, are an abundant superamily of proteins also known as [[G protein-coupled receptor|seven-transmembrane domain receptors]], [[G protein-coupled receptor|7TM receptors]], [[G protein-coupled receptor|heptahelical receptors]], [[G protein-coupled receptor|serpentine receptor]], and [[G protein-coupled receptor|G protein-linked receptors (GPLRs)]]. [[G protein-coupled receptor|G protein-coupled receptors]] are cell surface signalling proteins involved in many physiological functions and in multiple diseases. they are also the target of the majority of all modern [[[[Pharmaceutical Drugs|medicinal drugs]] <ref name="howmany">PMID: 17139284</ref><ref name="pharmtrends">PMID: 21075459</ref> . |
==See Also== | ==See Also== | ||
Revision as of 02:03, 7 September 2011
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G protein-coupled receptors, often abbreviated GPCRs, are an abundant superamily of proteins also known as seven-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein-linked receptors (GPLRs). G protein-coupled receptors are cell surface signalling proteins involved in many physiological functions and in multiple diseases. they are also the target of the majority of all modern [[medicinal drugs [1][2] .
Contents |
See Also
3D Structures of G protein-coupled receptors
References and Notes
- ↑ Overington JP, Al-Lazikani B, Hopkins AL. How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. PMID:17139284 doi:10.1038/nrd2199
- ↑ Peeters MC, van Westen GJ, Li Q, IJzerman AP. Importance of the extracellular loops in G protein-coupled receptors for ligand recognition and receptor activation. Trends Pharmacol Sci. 2011 Jan;32(1):35-42. PMID:21075459 doi:10.1016/j.tips.2010.10.001
Additional Literature
- PMID: xxxx
External Resources
- GPCRDB: database contains sequences, ligand binding constants and mutations, in addition GPCR multiple sequence alignments and homology models. Moreover, the site contains useful structure files where lysozyme and other inserts commonly used in the difficult process of crystallizing these transmembrane structures are removed.
- tinyGRAP GPCR mutant database.
- GPCR-OKB: GPCR Oligomerization Knowledge Base
- GPCR Natural Variants Database (NaVa)
- The PRED-GPCR server for GPCR recognition and family classification.
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