Complexin

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'''Complexin''' (CPLX) is the a protein which binds the SNARE protein complex with high affinity. CPLX acts as both inhibitor and facilitator of vescicle fusion and neurotransmitter release at the synapse. CPLX clamps SNARE complexes to prevent vescicle fusion while in another conformation it releases the SNARE complex allowing fusion.
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'''Complexin''' (CPLX) is the protein which binds the SNARE protein complex with high affinity. CPLX acts as both inhibitor and facilitator of vescicle fusion and neurotransmitter release at the synapse. CPLX clamps SNARE complexes to prevent vescicle fusion while in another conformation it releases the SNARE complex allowing fusion.
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Revision as of 07:29, 24 November 2011

Template:STRUCTURE 3rk3


Complexin (CPLX) is the protein which binds the SNARE protein complex with high affinity. CPLX acts as both inhibitor and facilitator of vescicle fusion and neurotransmitter release at the synapse. CPLX clamps SNARE complexes to prevent vescicle fusion while in another conformation it releases the SNARE complex allowing fusion.

Contents

3D structures of complexin

1kil – CPLX + SNARE – rat

3rk3, 3rl0 - CPLX + SNARE – human

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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