Spermidine/spermine N-acetyltransferase
From Proteopedia
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| + | {{STRUCTURE_3bj8| PDB=3bj8 | SIZE=400| SCENE= |right|CAPTION=Human SSAT1 complex with CoA and spermine, [[3bj8]] }} | ||
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Revision as of 09:32, 14 March 2012
Spermidine/spermine N-acetyltransferase (SSAT) catalyzes the acetylation of spermidine and spermine. SSAT regulates cellular polyamine homeostasis by degrading polyamines via their acetylation. SSAT activity is regulated by polyamine concentration and various toxins, hormones and natural products. Several types of cancer are accompanied by increased level of cellular polyamine and compounds which affect SSAT activity are explored as possible anti-cancer drugs.
3D structures of SSAT
2q4v, 2bei – hSSAT2 – human
2f5i, 2b5g, 2g3t – hSSAT1
2b3u – hSSAT1 (mutant)
SSAT complexes
2b3v - hSSAT1 (mutant) + acetyl-CoA
2fxf - hSSAT1 + acetyl-CoA
2b4b - hSSAT1 (mutant) + BE3 + CoA
2b4d, 2b58, 3bj7 - hSSAT1 + CoA
2jev - hSSAT1 + acetylspermine-S-CoA
3bj8 - hSSAT1 + spermine + CoA
