User:Anika Zohra Yasin/Sandbox1 3pb3
From Proteopedia
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==Sequence== | ==Sequence== | ||
* Ligand Information: S-ADENOSYL-L-HOMOCYSTEINE(SAH) | * Ligand Information: S-ADENOSYL-L-HOMOCYSTEINE(SAH) | ||
| + | |||
==Function== | ==Function== | ||
| - | * Methyltransferase Activity | + | * Methyltransferase Activity |
| + | 3pb3 acts as a methyltransferase also known as methylase which adds a methyl group to specific bases in their ribosomes. | ||
| + | |||
* Antibiotic Resistance | * Antibiotic Resistance | ||
| + | The antibiotic is unable to bind to the ribosomes rendering it ineffective. | ||
| + | |||
==Conclusion== | ==Conclusion== | ||
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==References== | ==References== | ||
Revision as of 20:37, 27 March 2012
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Contents |
Introduction
3Pb3 is a 16S rRNA methyltransferase. It methylates one nucleotide in bacterial ribosomes, creating resistance to some aminoglycoside antibiotics. This enzyme is part of the kanamycin-apramycin methyltransferase (Kam) family.
Biological Source
- E. Coli
Structure
Sequence
- Ligand Information: S-ADENOSYL-L-HOMOCYSTEINE(SAH)
Function
- Methyltransferase Activity
3pb3 acts as a methyltransferase also known as methylase which adds a methyl group to specific bases in their ribosomes.
- Antibiotic Resistance
The antibiotic is unable to bind to the ribosomes rendering it ineffective.
