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Introduction

The tetanus toxin, or Clostridium tetani, is produced by the bacteria Clostridium. Clostridium bacteria produces distinct neurotoxins that are extremely potent to humans. It releases two types of neurotoxins: Clostridium botulinum and Clostridium tetani. It is part of the peptidase M27 family of proteins, which are metalloproteases. Metalloproteases bind with a divalent cation, usually zinc, which activates water molecules within the active site to hydrolyze peptide bonds.

Clostridium tetani functions by inhibiting neurotransmitter release into the synaptic cleft of the spinal cord. It mimics a zinc peptidase

Structure

The Clostridium tetani precursor polypeptide is cleaved into a heavy and light chains. These two chains remain linked by a disulfide bridge. These chains are non-toxic when separated.

Mechanism of Action

Medical Implications or Possible Applications