• Click the edit this page tab at the top. Save the page after each step, then edit it again.
• Click the 3D button (when editing, above the wikitext box) to insert Jmol.
• show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
• Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing

For more help, look at this link: http://www.proteopedia.org/wiki/index.php/Help:Getting_Started_in_Proteopedia

Diphtheria toxin

Diphtheria Toxin is an exotoxin produced by the organism Corynebcterium diphtheria which has been infected by a bacteriophage that contains the Diphtheria toxin gene. It attacks and kills eukaryotic cells by inactivating the Elongation factor (EF-2) in translation. EF-2 allows for translocation of the peptidyl-tRNA from the A-site to the P-site, which in turn frees the A site for another aminoacyl-tRNA to bind. By inactivating the elongation factor during translation the protein being made cannot be completed and therefore becomes nonfunctional.

Histroy

Scientist have made efforts since at least the 1740's to find the caustion and cure for diphtheria toxin. It wasn't until Koch's devolpment of medical microbiology and Koch's postulates that it was even possible for progression towards understanding the molecular causes.