Sandbox Reserved 559

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(New page: <!-- PLEASE DO NOT DELETE THIS TEMPLATE --> {{NCSU_BIOL414_Sandbox}} <!-- PLEASE ADD YOUR CONTENT BELOW HERE --> Hi everyone, Here is your very own Proteopedia Page to play with. This page...)
Current revision (17:44, 24 May 2012) (edit) (undo)
 
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{{NCSU_BIOL414_Sandbox}}
{{NCSU_BIOL414_Sandbox}}
<!-- PLEASE ADD YOUR CONTENT BELOW HERE -->
<!-- PLEASE ADD YOUR CONTENT BELOW HERE -->
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Hi everyone,
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Hi Jacob,
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Here is your very own Proteopedia Page to play with.
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Here is your very own Proteopedia Page for pdb code: 2RH1.
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This page is not publicly available yet,
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Your presentation is scheduled for: June 20.
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so don't worry about making mistakes that
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other people will see.
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Have Fun!
Have Fun!
Greg Buhrman
Greg Buhrman
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[[Image:2rh1.png|left|200px]]
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<!--
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The line below this paragraph, containing "STRUCTURE_2rh1", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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{{STRUCTURE_2rh1| PDB=2rh1 | SCENE= }}
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===High resolution crystal structure of human B2-adrenergic G protein-coupled receptor.===
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<!--
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The line below this paragraph, {{ABSTRACT_PUBMED_17962520}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17962520 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17962520}}
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==About this Structure==
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[[2rh1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens,_enterobacteria_phage_t4 Homo sapiens, enterobacteria phage t4]. The April 2008 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Adrenergic Receptors'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2008_4 10.2210/rcsb_pdb/mom_2008_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RH1 OCA].
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==See Also==
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*[[Beta-2 Adrenergic Receptor]]
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*[[Group:SMART:A Physical Model of the β2-Adrenergic Receptor]]
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*[[Group:SMART:Tangible Models of Cdc42 Interacting With Intersectin]]
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*[[User:Frieda S. Reichsman]]
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==Reference==
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<ref group="xtra">PMID:017962520</ref><ref group="xtra">PMID:017962519</ref><references group="xtra"/>
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[[Category: Adrenergic Receptors]]
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[[Category: Homo sapiens, enterobacteria phage t4]]
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[[Category: RCSB PDB Molecule of the Month]]
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[[Category: ATCG3D, Accelerated Technologies Center for Gene to 3D Structure.]]
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[[Category: Cherezov, V.]]
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[[Category: Choi, H J.]]
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[[Category: Hanson, M A.]]
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[[Category: Kobilka, B K.]]
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[[Category: Kobilka, T S.]]
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[[Category: Kuhn, P.]]
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[[Category: Rasmussen, S G.F.]]
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[[Category: Rosenbaum, D M.]]
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[[Category: Stevens, R C.]]
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[[Category: Thian, F S.]]
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[[Category: Weis, W I.]]
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[[Category: 7tm]]
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[[Category: Accelerated technologies center for gene to 3d structure]]
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[[Category: Adrenergic]]
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[[Category: Atcg3d]]
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[[Category: Cholesterol]]
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[[Category: Fusion]]
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[[Category: Gpcr]]
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[[Category: Lipidic]]
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[[Category: Lipidic cubic phase]]
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[[Category: Membrane protein]]
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[[Category: Membrane protein / hydrolase complex]]
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[[Category: Mesophase]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-2]]
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[[Category: Structural genomic]]

Current revision

This Sandbox is Reserved from 05/22/2012, through 07/22/2012 for use in the course "BIOL 414" taught by Greg Buhrman at the North Carolina State University, Raleigh, NC USA. This reservation includes Sandbox Reserved 551 through Sandbox Reserved 590.
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
  • Click the 3D button (when editing, above the wikitext box) to insert Jmol.
  • show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
  • Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing

Hi Jacob, Here is your very own Proteopedia Page for pdb code: 2RH1. Your presentation is scheduled for: June 20.

Have Fun!

Greg Buhrman


PDB ID 2rh1

Drag the structure with the mouse to rotate
2rh1, resolution 2.40Å ()
Ligands: , , , , , , ,
Gene: ADRB2, ADRB2R, B2AR / E (Enterobacteria phage T4)
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



Contents

High resolution crystal structure of human B2-adrenergic G protein-coupled receptor.

Publication Abstract from PubMed

Heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors constitute the largest family of eukaryotic signal transduction proteins that communicate across the membrane. We report the crystal structure of a human beta2-adrenergic receptor-T4 lysozyme fusion protein bound to the partial inverse agonist carazolol at 2.4 angstrom resolution. The structure provides a high-resolution view of a human G protein-coupled receptor bound to a diffusible ligand. Ligand-binding site accessibility is enabled by the second extracellular loop, which is held out of the binding cavity by a pair of closely spaced disulfide bridges and a short helical segment within the loop. Cholesterol, a necessary component for crystallization, mediates an intriguing parallel association of receptor molecules in the crystal lattice. Although the location of carazolol in the beta2-adrenergic receptor is very similar to that of retinal in rhodopsin, structural differences in the ligand-binding site and other regions highlight the challenges in using rhodopsin as a template model for this large receptor family.

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor., Cherezov V, Rosenbaum DM, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Kuhn P, Weis WI, Kobilka BK, Stevens RC, Science. 2007 Nov 23;318(5854):1258-65. Epub 2007 Oct 25. PMID:17962520

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

2rh1 is a 1 chain structure with sequence from Homo sapiens, enterobacteria phage t4. The April 2008 RCSB PDB Molecule of the Month feature on Adrenergic Receptors by David S. Goodsell is 10.2210/rcsb_pdb/mom_2008_4. Full crystallographic information is available from OCA.

See Also

Reference

  • Cherezov V, Rosenbaum DM, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Kuhn P, Weis WI, Kobilka BK, Stevens RC. High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science. 2007 Nov 23;318(5854):1258-65. Epub 2007 Oct 25. PMID:17962520
  • Rosenbaum DM, Cherezov V, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Yao XJ, Weis WI, Stevens RC, Kobilka BK. GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function. Science. 2007 Nov 23;318(5854):1266-73. Epub 2007 Oct 25. PMID:17962519
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