Virus protease

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Crystal Structure of HIV-1 protease 1odw

Virus proteases include HIV protease, XMRV protease, retropepsin. HIV Protease (HIV-PR) and xenotropic murine leukemia virus protease (XMRV-PR) cleave polyproteins to produce the mature proteins of the virus. Both are aspartyl proteases. The inhibition of HIV-PR results in an uninfectious HIV virion. HIV-1 is found globally while HIV-2, which has lower virulence, is found in West Africa. See also

Human Immunodeficiency Virus
HIV-1 protease
HIV Protease Inhibitor Pharmacokinetics
HIV Protease Inhibitor Resistance Profile
HIV Protease Resistance
Molecular Playground/Dengue Virus Protease
Viability of a drug-resistant HIV-1 protease mutant

1 3D Structures of Virus proteases

3D Structures of Virus proteases

Update December 2011

HIV-1

3ixo - HIV1-PR subtype A
1odx, 2hb2, 2hb4, 2pc0, 3bva, 3mws, 3kt2, 3kt5 - HIV1-PR (mutant)
1rpi, 1rq9, 1tw7, 3oq7, 3oqa, 3oqd, 3pj6 - HIV1-PR (drug-resistant mutant)
1odw, 3kf1, 3hvp, 3phv - HIV1-PR
3fsm, 3hlo - HIV1-PR covalent dimer

HIV-1 complexes

1hsg, 1hsh, 1hsi, 3oxc, 3ekv, 3ekx, 3eky, 3el1, 1ohr - HIV1-PR + antiviral drug
1aid, 1qbr, 1qbs, 1qbt, 1qbu, 3mxe, 3m9f , 3kf0, 3kf1, 3kfn, 3kfp, 3kfr, 3kfs, 2wkz, 2wl0, 3gga, 3ggv, 3ggx, 2uxz, 2uy0, 1zp8, 1xl2, 1xl5, 1zpa, 1yt9, 2a4f , 1upj, 2upj, 7upj, 1hxb, 1hih, 1hvr, 1hef, 1heg, 4phv, 1w5w, 1w5x, 1w5v, 1w5y, 1t7k, 1npa, 1npv, 1npw, 1eby, 1ec0, 1g2k, 1c6x, 1c6y, 1c6z, 1hwr, 2bpv, 2bpw, 2bpx, 2bpy, 2bpz, 1ody, 1hvh, 3tlh, 1hxw, 3bvb, 3ckt, 3mxd, 3hau, 3haw, 3hbo, 3hdk, 3i2l, 3ia9, 3r4b, 3bgb, 3bgc, 3bhe, 3gi4, 3gi5, 3gi6, 3nwq, 3nwx, 3nyg - HIV1-PR + inhibitor
2zye - HIV1-PR + inhibitor - neutron
3aid, 1ytg, 1yth, 2nxd, 2nxl, 2nxm, 2fns, 2fnt, 1zj7, 1zlf, 1zpk, 1zsf, 1zsr, 1cpi, 1m0b, 1iiq, 1fqx, 1a30 - HIV1-PR + polypeptide derivative
3gi0 - HIV1-PR covalent dimer + polypeptide
3hzc, 3iaw, 3ka2, 3nxn - HIV1-PR covalent dimer + inhibitor
1sp5 - HIV1-PR + autoproteolytic peptide

HIV-1 (mutant) complexes

3nu3, 3nu4, 3nu5, 3nu6, 3nu9, 3nuj, 3nuo, 2qhc, 2qak, 2pym, 2pyn, 2q63, 2q64, 2fxd, 2fxe, 2fgu, 2fgv, 1sdt, 1sdu, 1sdv, 1d4y, 1d4s, 3cyw, 3cyx, 3d1x, 3d1y, 3d1z, 3d20, 3djk, 3dk1, 3n3i, 3oxv, 3oxw, 3oxx, 3oy4, 3k4v, 3lzs, 3lzu, 3lzv, 3so9, 3spk - HIV1-PR (mutant) + antiviral drug
2aid, 1hpo, 1tcx, 1gnm, 1gnn, 1gno, 1kzk, 3ok9, 3i8w, 3i7e, 3bxr, 3bxs, 2hc0, 2psu, 2psv, 2fle, 2f3k, 2ien, 2fdd, 2fde, 1t7i, 1t3r, 1mrw, 1mrx, 1msm, 1msn, 1bv9, 3h5b, 3kdb, 3kdc, 3kdd, 3a2o, 3bc4, 3fx5, 3i6o, 3st5- HIV1-PR (mutant) + inhibitor
2p3b - HIV1-PR subtype B (mutant) + inhibitor
2p3c - HIV1-PR subtype F (mutant) + inhibitor
1zbg, 1z8c, 2az9, 2azc, 2a1e, 1lzq, 1d4k, 1d4l, 1a8k, 1a94, 1axa, 3dox, 3d3t - HIV1-PR (mutant) + polypeptide derivative
1ztz - HIV1-PR (mutant) + autoproteolytic polypeptide + metalacarborane
3b7v, 3b80, 3mim - HIV1-PR (mutant) + autoproteolytic polypeptide + tetrahedral intermediate
3nxe - HIV1-PR covalent dimer (mutant) + inhibitor

HIV-1 (drug-resistant mutant) complexes

3el4, 3el9, 3em3, 3em4, 3em6, 3ggt, 3ggu, 1t7j, 1rv7, 1n49, 1fb7, 3ekp, 3ekq, 3ekt, 3ekw, 3el0, 3el5, 3pwm, 3pwr - HIV1-PR (drug-resistant mutant) + antiviral drug
3ots, 3oty, 3ou1, 3ou3, 3ou4, 3oua, 3oub, 3ouc, 3oud - HIV1-PR (drug-resistant mutant) + peptide
1izh, 1izi, 1fb7 - HIV1-PR (drug-resistant mutant) + inhibitor
2p3a - HIV1-PR subtype B (drug-resistant mutant) + inhibitor
2p3d - HIV1-PR subtype F (drug-resistant mutant) + inhibitor

HIV-2

1jld - HIV2-PR
1hii - HIV2-PR + inhibitor
5upj, 6upj, 3upj, 4upj - HIV2-PR (mutant) + inhibitor
1ida, 1idb, 2mip - HIV2-PR + polypeptide derivative

Feline Immunodeficiency Virus-PR

2hah, 4fiv - FIV-PR residues 39-154 (mutant) + inhibitor
3ogp, 3ogq - FIV-PR residues 39-154 (mutant) + drug
5fiv, 6fiv, 1b11 - FIV-PR + inhibitor
2fiv, 3fiv - SIV-PR (mutant) + substrate

Simian Immunodeficiency Virus-PR

2sam - SIV-PR + inhibitor
1az5 - SIV-PR (mutant)

XMRV-PR

3nr6 – XMRV-PR P14
3p1g – XMRV-PR RNase H domain (mutant)

Rous sarcoma virus protease

1bai – RSVP + polypeptide inhibitor _ Rous sarcoma virus

Human Cytomegalovirus protease

1cmv, 1lay – CMVP (mutant) – human herpes virus 5
1wpo – CMVP
2wpo - CMVP (mutant) + inhibitor

Varicella-Zoster virus protease

1vzv - VZVP (mutant) – human herpes virus

Equine infectious anemia virus protease

2fmb – EIAVP (mutant) + inhibitor

Hepatitis A virus protease

2h9h – HAVP residues 1520-1731 (mutant) + polypeptide inhibitor

Orf 17

3njq – hOrf 17 - human herpes virus 8

Dengue virus protease

3u1i – DvNs2b + peptide – Dengue virus
3u1j – DvNs2b + BPTI
2fom - DvNs2b + DvNs3

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky

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	[[Image:1odw.png\|left\|200px\|thumb\|Crystal Structure of HIV-1 protease [[1odw]]]]		[[Image:1odw.png\|left\|200px\|thumb\|Crystal Structure of HIV-1 protease [[1odw]]]]
	{{STRUCTURE_1odw\| PDB=1odw \| SIZE=400\| SCENE=Virus_protease/Cv/1 \|right\|CAPTION=HIV-1 protease complex with tert-butylcarbonate [[1odw]] }}		{{STRUCTURE_1odw\| PDB=1odw \| SIZE=400\| SCENE=Virus_protease/Cv/1 \|right\|CAPTION=HIV-1 protease complex with tert-butylcarbonate [[1odw]] }}
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