3jsu

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Revision as of 18:42, 25 July 2012

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Template:STRUCTURE 3jsu

Contents 1 Quadruple mutant(N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate synthase(PFDHFR-TS) complexed with QN254, NADPH, and dUMP 2 About this Structure 3 See Also 4 Reference

Quadruple mutant(N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate synthase(PFDHFR-TS) complexed with QN254, NADPH, and dUMP

Template:ABSTRACT PUBMED 20350951

About this Structure

3jsu is a 2 chain structure of Dihydrofolate reductase and Thymidylate synthase with sequence from Plasmodium falciparum. Full crystallographic information is available from OCA.

See Also

• Dihydrofolate reductase
• Thymidylate synthase

Reference

• Nzila A, Rottmann M, Chitnumsub P, Kiara SM, Kamchonwongpaisan S, Maneeruttanarungroj C, Taweechai S, Yeung BK, Goh A, Lakshminarayana SB, Zou B, Wong J, Ma NL, Weaver M, Keller TH, Dartois V, Wittlin S, Brun R, Yuthavong Y, Diagana TT. Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate. Antimicrob Agents Chemother. 2010 Jun;54(6):2603-10. Epub 2010 Mar 29. PMID:20350951 doi:10.1128/AAC.01526-09