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3dl5
From Proteopedia
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{{STRUCTURE_3dl5| PDB=3dl5 | SCENE= }} | {{STRUCTURE_3dl5| PDB=3dl5 | SCENE= }} | ||
===Crystal Structure of the A287F Active Site Mutant of TS-DHFR from Cryptosporidium hominis=== | ===Crystal Structure of the A287F Active Site Mutant of TS-DHFR from Cryptosporidium hominis=== | ||
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{{ABSTRACT_PUBMED_18672899}} | {{ABSTRACT_PUBMED_18672899}} | ||
==About this Structure== | ==About this Structure== | ||
| - | [[3dl5]] is a 5 chain structure of [[Dihydrofolate reductase]] with sequence from [http://en.wikipedia.org/wiki/Cryptosporidium_hominis Cryptosporidium hominis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DL5 OCA]. | + | [[3dl5]] is a 5 chain structure of [[Dihydrofolate reductase]] and [[Thymidylate synthase]] with sequence from [http://en.wikipedia.org/wiki/Cryptosporidium_hominis Cryptosporidium hominis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DL5 OCA]. |
==See Also== | ==See Also== | ||
| - | *[[Dihydrofolate reductase]] | + | *[[Dihydrofolate reductase|Dihydrofolate reductase]] |
| + | *[[Thymidylate synthase|Thymidylate synthase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:018672899</ref><references group="xtra"/> |
[[Category: Cryptosporidium hominis]] | [[Category: Cryptosporidium hominis]] | ||
[[Category: Dihydrofolate reductase]] | [[Category: Dihydrofolate reductase]] | ||
Revision as of 03:30, 27 July 2012
Contents |
Crystal Structure of the A287F Active Site Mutant of TS-DHFR from Cryptosporidium hominis
Template:ABSTRACT PUBMED 18672899
About this Structure
3dl5 is a 5 chain structure of Dihydrofolate reductase and Thymidylate synthase with sequence from Cryptosporidium hominis. Full crystallographic information is available from OCA.
See Also
Reference
- Martucci WE, Vargo MA, Anderson KS. Explaining an unusually fast parasitic enzyme: folate tail-binding residues dictate substrate positioning and catalysis in Cryptosporidium hominis thymidylate synthase. Biochemistry. 2008 Aug 26;47(34):8902-11. Epub 2008 Aug 2. PMID:18672899 doi:10.1021/bi800466z
