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2ano
From Proteopedia
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===Crystal structure of E.coli dihydrofolate reductase in complex with NADPH and the inhibitor MS-SH08-17=== | ===Crystal structure of E.coli dihydrofolate reductase in complex with NADPH and the inhibitor MS-SH08-17=== | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | [[2ano]] is a 1 chain structure of [[Dihydrofolate reductase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ANO OCA]. | |
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| + | ==See Also== | ||
| + | *[[Dihydrofolate reductase|Dihydrofolate reductase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:017125251</ref><ref group="xtra">PMID:016126221</ref><references group="xtra"/> |
[[Category: Dihydrofolate reductase]] | [[Category: Dihydrofolate reductase]] | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
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[[Category: Summerfield, R L.]] | [[Category: Summerfield, R L.]] | ||
[[Category: Dhfr]] | [[Category: Dhfr]] | ||
| + | [[Category: Oxidoreductase]] | ||
[[Category: Protein inhibitor complex]] | [[Category: Protein inhibitor complex]] | ||
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Revision as of 15:37, 27 July 2012
Contents |
Crystal structure of E.coli dihydrofolate reductase in complex with NADPH and the inhibitor MS-SH08-17
Template:ABSTRACT PUBMED 17125251
About this Structure
2ano is a 1 chain structure of Dihydrofolate reductase with sequence from Escherichia coli. Full crystallographic information is available from OCA.
See Also
Reference
- Summerfield RL, Daigle DM, Mayer S, Mallik D, Hughes DW, Jackson SG, Sulek M, Organ MG, Brown ED, Junop MS. A 2.13 A structure of E. coli dihydrofolate reductase bound to a novel competitive inhibitor reveals a new binding surface involving the M20 loop region. J Med Chem. 2006 Nov 30;49(24):6977-86. PMID:17125251 doi:10.1021/jm060570v
- Pant K, Crane BR. Structure of a loose dimer: an intermediate in nitric oxide synthase assembly. J Mol Biol. 2005 Sep 30;352(4):932-40. PMID:16126221 doi:10.1016/j.jmb.2005.07.070
