Sandbox Zdenek
From Proteopedia
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<StructureSection load='3nw0' size='350' side='right' caption='Structure of MAGEG1 complex with Nse1 subunit(PDB entry [[3nw0]])' scene=''> | <StructureSection load='3nw0' size='350' side='right' caption='Structure of MAGEG1 complex with Nse1 subunit(PDB entry [[3nw0]])' scene=''> | ||
Melanoma associated antigen (MAGE) proteins are associated with DNA replication processes. This family of proteins contains more than 60 species divided into 6 families. As described in <ref> pmid 20864041</ref> The family is characterised by [[Coiled_coil]] <scene name='Sandbox_Zdenek/Scene3/1'>structural motif</scene>. | Melanoma associated antigen (MAGE) proteins are associated with DNA replication processes. This family of proteins contains more than 60 species divided into 6 families. As described in <ref> pmid 20864041</ref> The family is characterised by [[Coiled_coil]] <scene name='Sandbox_Zdenek/Scene3/1'>structural motif</scene>. | ||
| + | Genes of these proteins were firstly indentified in varius kind of tumors. At this time their have been described as completely silent in normal adult tissues, with the exception of male germ cells and, for some of them, placenta. The only region of homology shared by all of the members of the family is a stretch of about 200 amino acids which has been named the MAGE conserved domain. The MAGE conserved domain is usually located close to the C-terminal, although it can also be found in a more central position in some proteins. The MAGE conserved domain is generally present as a single copy but it is duplicated in some proteins. | ||
</StructureSection> | </StructureSection> | ||
<scene name='Sandbox_Zdenek/Scene1/3'>MAGE-G1 unit</scene> and <scene name='Sandbox_Zdenek/Scene2/3'>Nse1 subunit</scene> | <scene name='Sandbox_Zdenek/Scene1/3'>MAGE-G1 unit</scene> and <scene name='Sandbox_Zdenek/Scene2/3'>Nse1 subunit</scene> | ||
<references/> | <references/> | ||
Revision as of 11:38, 6 September 2012
Your Heading Here (maybe something like 'Structure')
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- ↑ Doyle JM, Gao J, Wang J, Yang M, Potts PR. MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. Mol Cell. 2010 Sep 24;39(6):963-74. PMID:20864041 doi:10.1016/j.molcel.2010.08.029
