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The SMC5-6 protein complex is one of the three SMC (Structural maintenance of chromosomes) protein complexes present in all eukaryotes <ref>pmid 18059412</ref> , <ref> pmid 19308705 </ref>. The SMC5-6 complex is involved in chromatin dynamics such as the response to different types of DNA damage <ref> pmid 15661654 </ref>, <ref> pmid 8524274 </ref> . The core of the complex is formed by the SMC5-SMC6 heterodimer, which is associated with four conserved non-SMC proteins <ref> pmid 10747036 </ref>.<scene name='Sandbox_Zdenek/Scene2/4'>Nse1 subunit</scene> together with <scene name='Sandbox_Zdenek/Scene1/5'>MAGE-G1 subunit</scene> (homologue of Nse3) formed tight part of this complex. [[Image:smc_complex.png|200px|left|Scheme of SMC5-6 complex]]. | The SMC5-6 protein complex is one of the three SMC (Structural maintenance of chromosomes) protein complexes present in all eukaryotes <ref>pmid 18059412</ref> , <ref> pmid 19308705 </ref>. The SMC5-6 complex is involved in chromatin dynamics such as the response to different types of DNA damage <ref> pmid 15661654 </ref>, <ref> pmid 8524274 </ref> . The core of the complex is formed by the SMC5-SMC6 heterodimer, which is associated with four conserved non-SMC proteins <ref> pmid 10747036 </ref>.<scene name='Sandbox_Zdenek/Scene2/4'>Nse1 subunit</scene> together with <scene name='Sandbox_Zdenek/Scene1/5'>MAGE-G1 subunit</scene> (homologue of Nse3) formed tight part of this complex. [[Image:smc_complex.png|200px|left|Scheme of SMC5-6 complex]]. | ||
| - | Melanoma associated antigen (MAGE) proteins are associated also with DNA replication processes. This family of proteins contains more than 60 species divided into 6 families. As described in <ref> pmid 20864041</ref> The family is characterised by [[Coiled_coil]] <scene name='Sandbox_Zdenek/Scene4/ | + | Melanoma associated antigen (MAGE) proteins are associated also with DNA replication processes. This family of proteins contains more than 60 species divided into 6 families. As described in <ref> pmid 20864041</ref> The family is characterised by [[Coiled_coil]] <scene name='Sandbox_Zdenek/Scene4/4'>structural motif</scene>. |
Genes of these proteins were firstly indentified in varius kind of tumors. At this time their have been described as completely silent in normal adult tissues, with the exception of male germ cells and, for some of them, placenta. The only region of homology shared by all of the members of the family is a stretch of about 200 amino acids which has been named the MAGE conserved domain. The MAGE conserved domain is usually located close to the C-terminal, although it can also be found in a more central position in some proteins. The MAGE conserved domain is generally present as a single copy but it is duplicated in some proteins. | Genes of these proteins were firstly indentified in varius kind of tumors. At this time their have been described as completely silent in normal adult tissues, with the exception of male germ cells and, for some of them, placenta. The only region of homology shared by all of the members of the family is a stretch of about 200 amino acids which has been named the MAGE conserved domain. The MAGE conserved domain is usually located close to the C-terminal, although it can also be found in a more central position in some proteins. The MAGE conserved domain is generally present as a single copy but it is duplicated in some proteins. | ||
Revision as of 13:42, 6 September 2012
Structural maintenance of chromosomes protein complexes
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- ↑ Murray JM, Carr AM. Smc5/6: a link between DNA repair and unidirectional replication? Nat Rev Mol Cell Biol. 2008 Feb;9(2):177-82. PMID:18059412 doi:10.1038/nrm2309
- ↑ De Piccoli G, Torres-Rosell J, Aragon L. The unnamed complex: what do we know about Smc5-Smc6? Chromosome Res. 2009;17(2):251-63. PMID:19308705 doi:10.1007/s10577-008-9016-8
- ↑ Lehmann AR. The role of SMC proteins in the responses to DNA damage. DNA Repair (Amst). 2005 Mar 2;4(3):309-14. PMID:15661654 doi:10.1016/j.dnarep.2004.07.009
- ↑ Lehmann AR, Walicka M, Griffiths DJ, Murray JM, Watts FZ, McCready S, Carr AM. The rad18 gene of Schizosaccharomyces pombe defines a new subgroup of the SMC superfamily involved in DNA repair. Mol Cell Biol. 1995 Dec;15(12):7067-80. PMID:8524274
- ↑ Fousteri MI, Lehmann AR. A novel SMC protein complex in Schizosaccharomyces pombe contains the Rad18 DNA repair protein. EMBO J. 2000 Apr 3;19(7):1691-702. PMID:10747036 doi:10.1093/emboj/19.7.1691
- ↑ Doyle JM, Gao J, Wang J, Yang M, Potts PR. MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. Mol Cell. 2010 Sep 24;39(6):963-74. PMID:20864041 doi:10.1016/j.molcel.2010.08.029
