Adrenergic receptor
From Proteopedia
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[[3ny8]], [[3ny9]], [[3nya]] – hB2AR + agonist<br /> | [[3ny8]], [[3ny9]], [[3nya]] – hB2AR + agonist<br /> | ||
[[3sn6]] - human β-2 adrenergic receptor + cameloid antibody fragment bound by guanine nucleotide-binding protein G. '''This is the first structure of an activated GPCR in a complex with its G protein.''' | [[3sn6]] - human β-2 adrenergic receptor + cameloid antibody fragment bound by guanine nucleotide-binding protein G. '''This is the first structure of an activated GPCR in a complex with its G protein.''' | ||
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| + | ==See Also== | ||
| + | * [[G protein-coupled receptor]] | ||
| + | * [[Nobel Prizes for 3D Molecular Structure]] | ||
| + | * [[Highest impact structures]] of all time | ||
| + | *[[Rhodopsin]] | ||
| + | *[[Pharmaceutical Drugs]] | ||
| + | *[[Membrane proteins]] | ||
| + | *[[Hormone]] | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 13:28, 10 October 2012
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| β-2 Adrenergic Receptor, 2rh1 | |||||||||
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| Ligands: | , , , , , , , | ||||||||
| Gene: | ADRB2, ADRB2R, B2AR / E (Enterobacteria phage T4) | ||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
The adrenergic receptors are metabolic G protein-coupled receptors. They are the targets of catecholamines. The binding of an agonist to them causes a sympathetic response. The α-2 adrenergic receptor (A2AR) inhibits insulin or glucagons release. The β-1 adrenergic receptor (B1AR) increases cardiac output and secretion of rennin and ghrelin. The β-2 adrenergic receptor (B2AR) triggers many relaxation reactions. The images at the left and at the right correspond to one representative Adrenergic receptor, i.e. the crystal structure of human β-2 adrenergic Receptor (2rh1). See also Beta-2 Adrenergic Receptor and G protein-coupled receptor. (morph was taken from Gallery of Morphs of the Yale Morph Server).
Contents |
3D Structures of Adrenergic receptor
Update November 2011
α-2 adrenergic receptor
3kj6, 2r4r, 2r4s – hA2AR + FAB heavy+light chains
1ho9, 1hod – hA2AR peptide (mutant) – NMR
1hof, 1hll - hA2AR peptide – NMR
β-1 adrenergic receptor
2y01 – tB1AR fragment (mutant) – turkey
1dep – tB1AR peptide - NMR
2y00, 2y02, 2y03, 2y04, 2vt4 - tB1AR fragment (mutant) + agonist
2ycw, 2ycx, 2ycz, 2ycy - tB1AR fragment (mutant) + antagonist
β-2 adrenergic receptor
See also Beta-2 Adrenergic Receptor
3pds - hB2AR/T4 lysozyme - human
3p0g – hB2AR/T4 lysozyme + cameloid antibody fragment
2r4s,2r4r - hB2AR + Fab5 complex
2rh1 - hB2AR/T4 lysozyme (mutant)
3d4s - hB2AR/T4 lysozyme (mutant) + cholesterol
3ny8, 3ny9, 3nya – hB2AR + agonist
3sn6 - human β-2 adrenergic receptor + cameloid antibody fragment bound by guanine nucleotide-binding protein G. This is the first structure of an activated GPCR in a complex with its G protein.
See Also
- G protein-coupled receptor
- Nobel Prizes for 3D Molecular Structure
- Highest impact structures of all time
- Rhodopsin
- Pharmaceutical Drugs
- Membrane proteins
- Hormone
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Wayne Decatur, Karsten Theis, Alexander Berchansky
