GTP-binding protein
From Proteopedia
m |
m |
||
| Line 80: | Line 80: | ||
[[3sn6]] - human β-2 adrenergic receptor + cameloid antibody fragment bound by guanine nucleotide-binding protein G. '''This is the first structure of an activated [[G protein-coupled receptor]] in a complex with its G protein.''' | [[3sn6]] - human β-2 adrenergic receptor + cameloid antibody fragment bound by guanine nucleotide-binding protein G. '''This is the first structure of an activated [[G protein-coupled receptor]] in a complex with its G protein.''' | ||
| - | ==G protein bound to a G protein-coupled receptor== | + | ===G protein bound to a G protein-coupled receptor=== |
[[3sn6]] - human β-2 adrenergic receptor + cameloid antibody fragment bound by guanine nucleotide-binding protein G. '''This is the first structure of an activated [[G protein-coupled receptor]] in a complex with its G protein.''' | [[3sn6]] - human β-2 adrenergic receptor + cameloid antibody fragment bound by guanine nucleotide-binding protein G. '''This is the first structure of an activated [[G protein-coupled receptor]] in a complex with its G protein.''' | ||
{{Template:GPCR3sn6}} | {{Template:GPCR3sn6}} | ||
Revision as of 15:04, 10 October 2012
GTP-binding proteins or G proteins are transmitting signals outside the cell which cause changes within the cell. They act as molecular switches which are on when binding GTP and off when binding GDP. GTP-binding proteins belong to two families: heterotrimeric G proteins and small GTPases. The images at the left and at the right correspond to one representative G protein, i.e. the crystal structure of human GTP-binding protein complex with nucleotide (2nzj). See details on GTP-binding protein LpeD in LepA.
3D Structures of GTP-binding protein
Updated November 2011
GTP-binding protein
3r7w – yGtr1 + Gtr2 – yeast
2eki – hGBP TGS domain – NMR - human
3kxk, 3kxl – SsHflx (mutant) - Sulfolobus solfataricus
2qtf – SsHflx
1ega – EcERA – Escherichia coli
2dyk – TtEngA N terminal – Thermus thermophilus - Cryo EM
3cb4 - EcLepA
2ywe – AaLepA
1sul – BsYsxC - Bacillus subtilis
2dwq – TtYchF
1udx – TtObg
1wxq – GBP – Pyrococcus horikoshii
1ni3 – YchF – Schizosaccharomyces pombe
GTP-binding protein complex with nucleotide
2nzj – hRem1 + GDP
3cbq – hRem2 + GDP
3q85 – hRem2 G domain + GTP analog
2cjw, 2ht6, 2g3y – hGem G domain + GDP
2ohf – hOla1 + AMP-PCP
1xtq – hRheB + GDP
1xts - hRheB + GTP
1xtr - hRheB + GPPNHP
1e0a – hGBP (mutant) + GIP
2b8w, 2d4h – hGBP N terminal + GMP
2b92 - hGBP N terminal + GDP
2bc9 - hGBP N terminal + GPPNHP
3kxi, 2qth – SsHflx + GDP
3ieu – EcERA + GDP
3iev – AaERA + RNA + Mg-GNP – Aquifex aeolicus
1x1l – TtERA + RNA – Cryo EM
2ywf – AaLepA + GMP-PNP
2ywg - AaLepA + GTP
2ywh - AaLepA + GDP
1yzn – yPt1 + GPPNHP
1ky2 – yPt7 + GPPNHP
1ky3 – yPt7 + GDP
3rwm, 3rwo – yPt32 + GPPNHP
1ek0 – yPt51 + GPPNHP
2hjg – BsEngA + GDP
1svi – BsYsxC + GDP
1svw – BsYsxC + GMPPNP
1lnz – BsObg + GTP
2dby – TtYchF + GDP
1wf3 – Tt1341 + GNP
2gao - hSar1A + GDP
2fa9 – ChSar1B (mutant) + GDP – Chinese hamster
2fmx - ChSar1B + GDP
1byu – Ran + GDP - dog
GTP-binding protein complex with protein
1ees – hCdc42 + MapK3 peptide - NMR
1x18 – TtERA + RNA + RPS2 + RPS7 + RPS11 + RPS18 – Cryo EM
3deg – EcLepA + A-tRNA + P-tRNA + RPS12 + RPL11 – Cryo EM
3cue – yPt1 + transport protein subunits
2bcg, 1ukv - yPt1 + secretory pathway GDP-dissociation inhibitor
3cpj – yPt31 + Rab GDP-dissociation inhibitor
1m2o – ySar1 + protein transport protein sec23
3syn – BsFlhf + ATP-binding protein
3sn6 - human β-2 adrenergic receptor + cameloid antibody fragment bound by guanine nucleotide-binding protein G. This is the first structure of an activated G protein-coupled receptor in a complex with its G protein.
G protein bound to a G protein-coupled receptor
3sn6 - human β-2 adrenergic receptor + cameloid antibody fragment bound by guanine nucleotide-binding protein G. This is the first structure of an activated G protein-coupled receptor in a complex with its G protein.
| |||||||||||
| |||||||||||
Ras-related GTP-binding protein
3llu – hC nucleotide-binding domain
Ras-related GTP-binding protein complex with nucleotide
2l0x – Rheb + GDP – rat
2gjs – hRad1 + GDP
3q72, 3q7p, 3q7q – hRad G-domain + GTP analog
2dpx – hRad GTPase domain
2gf0 – hDiRas1 + GDP
2erx – hDiRas2 + Pi + GDP
1x3s – hRab-18 + GPPNHP
1yu9 - hRab-4A + GPPNHP
2atx – hTc10 + GPPNHP
1g16 – ySec4 + GDP
1g17 - ySec4 + GIP
Ras-related GTP-binding protein complex with protein
3kuc – hRap-1A + proto oncogene Ser/Thr protein kinase
3cf6 - hRap-1A + Rap guanine nucleotide exchange factor 4
3brw - hRap-1B + Rap GTPase-activating protein
1z0k – hRab-4 + rabenosyn-5
Interferon-induced GTP-binding protein
3ljb – hMx1 stalk region
Rho-related GTP-binding protein
2j1l – hRhoD
Rho-related GTP-binding protein complex with nucleotide
2cls – hRho6 + GTP
2fv8 - hRhoB + GDP
2gcn – hRhoC + GDP
2gco – hRhoC + GPPNHP
1z2c - hRhoC (mutant) + GMPPNP
2gcp – hRhoC + GSP
1m7b - hRhoE + GTP
1gwn - RhoE + GTP - mouse
1a4r - hCdc42 (mutant) + GDP
1an0 - hCdc42 + GDP
Rho-related GTP-binding protein complex with protein
2v55 – hRhoE + Rho-associated protein kinase
3q3j – hRho6 + plexin-A2 nucleotide-binding domain
2rex – hRho6 + plexin-B1
1cc0 – hRhoA + GDP-dissociation inhibitor + GDP
3a58 – yRho1 (mutant) + exocyst complex component Sec3
1gzs – Cdc42 + guanine nucleotide exchange factor – Salmonella typhimurium
2kb0 - hCdc42 (mutant)
1kz7 - hCdc42 + guanine nucleotide exchange factor
1kzg - hCdc42 (mutant) + guanine nucleotide exchange factor (mutant)
2dfk – hCdc42 + collybistin II
2wm9, 2wmn, 2wmo - hCdc42 + DOCK9
3eg5 - hCdc42 + protein diaphanous homolog 1 + GMPPNP
3gcg - hCdc42 + MAP
3n3v - hCdc42 + AMP-protein transferase
1nf3 - hCdc42 + Par6
2ase - hCdc42 (mutant) - NMR
1ki1 – hCdc42 + intersectin long form
1ees – hCdc42 + MapK3 peptide - NMR
1doa - hCdc42 + GDP-dissociation inhibitor
Rac-like GTP-binding protein
2wbl – AtArac2 + Rho of plant guanine nucleotide exchange factor 8 – Arabidopsis thaliana
3bwd – AtArac6
2nty – AtArac5 + prone8
2j0v – AtArac7 (mutant)
Rab-related GTP-binding protein
2ys8 – hRabJ DNAJ domain – NMR
Flagella-associated GTP-binding protein
2px0 – BsFlhF + GMP-PNP
2px3 – BsFlhF + GTP
See Also
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, Wayne Decatur, Jaime Prilusky
